Eastman announces new BoPhoz chiral ligands

08-Nov-2001

Eastman Chemical Company today announced the availability of BoPhoz chiral ligands, a family of chiral ligands used in asymmetric catalysis. The BoPhoz family of chiral ligands possesses a unique phosphine-aminophosphine substructure that imparts attributes not commonly found in other chiral catalysts. Among those attributes are:

-Shelf stability. BoPhoz chiral ligands show a surprising degree of shelf stability, even at ambient temperature and open to the air.

-High enantioselectivity. Asymmetric hydrogenation reactions conducted with BoPhoz chiral ligands typically show enantiomeric excesses equal to or higher than any competitive materials.

-Ease of use. Use of BoPhoz chiral ligands requires no elaborate protection from the atmosphere, unlike other comparable materials.

-Cost-effectiveness. The BoPhoz ligands are easily prepared and can be readily scaled up from lab to pilot to commercial quantities.

BoPhoz chiral ligands are particularly effective in the preparation of a wide variety of chiral amino acid derivatives, many of which are found in new pharmaceuticals. J. Stewart Witzeman, Ph.D., technology director of Eastman's performance chemicals and intermediates business, said, "This exciting discovery, made in Eastman's research laboratories, has stirred tremendous interest in the pharmaceutical community. Now researchers have a potential new path to produce new active pharmaceutical ingredients more quickly and cost-effectively, while being confident in Eastman's ability to provide sufficient quantities of chiral ligands at any scale required."

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