How Pharmaceutical Companies Can Sell a Drug Before it is Approved

11-Feb-2005

How can a start-up, cash hungry, biotech company generate much needed revenues? Dr. Gene Emmer President of Med Services Europe B.V. advises them to consider if a European "named patient program" might be an option.

A named-patient program allows physicians and their patients access to drugs which have not yet received approval for marketing by national health authorities. "European Named Patient Programs, like US compassionate use programs, offer physicians access to pharmaceuticals which have not yet been licensed" explained Dr. Emmer, "However, there is one important difference: in Europe an unlicensed drug is often purchased by National Health Systems." This presents drug-makers with an opportunity to generate revenues while development is still in-progress.

The additional revenues can be considerable. For example, a source at Pharmion, a US based company focusing on Oncology and Hematology reported dramatic increases in its Thalidomide sales from $1.9 million in 2Q '03 to $15.3 million in 2Q '04, primarily due to named patient sales in Europe for Multiple Myeloma. Thalidomide sales accounted for approximately 75% of Pharmion's total revenues for the first half of 2004, according to company sources, and were generated while the product awaits marketing approval for this indication. Before receiving European Marketing Approval, Shire's Argylin® for essential thrombocythaemia generated about 5% of its total sales from its European named patient program.

A named patient program can speed uptake after official launch. Physicians, who have had experience before launch, via clinical trials or named patient programs, often become early adopters and references for other physicians once the drug is freely circulating.

Named patient programs, like US compassionate use programs, can increase good-will toward the company because they simplify the process of gaining access for patients in critical need. Smaller companies often can not afford the administrative time and costs of shipping drugs around the world before launch. This can lead to frustration and resentment towards a company that many physicians will remember long after a drug is officially on the market. Creating a formal channel eliminates the unfortunate need of denying requests and risking ill-will later.

A named patient program should be considered an important part of a pre-launch program. It increases awareness to a pharmaceutical's existence, creates excitement, generates good-will and speeds penetration of the product after launch.

If one of the objectives is to generate revenues, setting up a named patient program is just the beginning. In order to achieve success, physicians need to be aware of the product and what they need to do to get it. Typical methods of informing physicians, such as sales rep visits and ads, may not be appropriate because a license is necessary to market a drug. While physicians are used to simply writing a prescription and being done with it, named patient programs require paper-work that some find tedious. Therefore the company needs to create an appropriate communication plan and work closely with the targeted medical community to keep them informed and simplify the process.

https://www.chemeurope.com/en/news/43375/how-pharmaceutical-companies-can-sell-a-drug-before-it-is-approved.html