PerkinElmer and MDS Sciex Announce Development of Next-Generation

04-Feb-2003

PerkinElmer, Inc. and MDS Sciex announced the development of a unique technology advancement for proteomics, the prOTOF(TM) 2000 MALDI O-TOF mass spectrometer for protein identification. As the first single MALDI-TOF mass spectrometer with an orthogonal design, the prOTOF 2000 represents a substantial leap forward from conventional MALDI-TOF in mass accuracy and stability across a wide mass range, making possible much higher rates of successful protein identification.

The new technology was announced at the LabAutomation conference on emerging laboratory technology, held in Palm Springs, Calif., February 1-5, 2003.

The prOTOF 2000 is the result of a joint venture between PerkinElmer and MDS Sciex, a collaboration to advance tools for proteomics. The partnership combines MDS Sciex's innovative and leading-edge mass spectrometry technology with PerkinElmer's expertise in proteomics, sample preparation technology, reagents, front-end chromatography, and intelligence software.

"This proprietary technology will provide customers with improved instrument performance across all parameters on a platform that is more stable than any current product," said Peter Coggins, Ph.D., president of PerkinElmer Life and Analytical Sciences. "The prOTOF 2000 overcomes key productivity barriers in traditional MALDI-TOF protein identification with higher mass accuracy, better low-abundance identification, integrated bioinformatics, and easier-to-use software."

The prOTOF 2000 enables an increased level of precision in peptide mass fingerprinting, allowing for more accurate matching and identification, while minimizing the need to run samples multiple times. In addition, prOTOF 2000 will provide the user with a software platform, TOFworks(TM), that integrates sample tracking, database search results and customized reports in an intuitive, easy-to-use interface.

Sampling flexibility has been provided for plate sizes ranging from 96- to 1536-wells, providing a high degree of freedom in sample preparation. The single-use MALDIchip(TM) disposable plates provide a convenient way to standardize sample preparation, minimize the chance of cross-contamination from a previously used plate, and store recently run samples.

Demonstrations and customer sample measurements are scheduled to begin in April, with system deliveries targeted to begin later in the spring.

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