Breaking down plastic waste
Organo-ruthenium mediated hydrogenation under mild conditions
Nagoya University
Building on their previous work, a research team at Nagoya University recently developed a series of organometallic ruthenium catalysts to break down even the toughest amide bonds effectively under mild conditions.
"Our previous catalysts could hydrogenate most amide bonds, but the reactions needed a long time at high temperature and high pressure. This new ruthenium catalyst can hydrogenate difficult substrates under much milder conditions," says lead author Takashi Miura.
Hydrogenation is the key step leading to breakdown of amide bonds. The catalyst features a ruthenium atom supported in an organic framework. This ruthenium atom can adsorb hydrogen and deliver it to the amide bond to initiate the breakdown. The team probed the position of hydrogen on the catalyst in the reaction pathway and modified the shape of the supporting framework. By making sure that the hydrogen molecule was is the best possible position for interaction with amide bonds, the team achieved much more effective hydrogenation.
Group leader Susumu Saito says, "The changes we made to the catalyst allowed some tricky amide bonds to be selectively cleaved for the first time. This catalyst has great potential for making designer peptides for pharmaceutics and could also be used to recover materials from waste plastics to help realize an anthropogenic chemical carbon cycle."
Original publication
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