Reducing antidepressants’ side effects
Heidi Hamm , Ph.D., Ana Carneiro, Ph.D., and colleagues used pharmacological and genetic models to show that chronic SSRI treatment causes decreased levels of a serotonin receptor (5-HT2AR) on platelets. They showed that inhibiting SERT increases extracellular serotonin, which desensitizes the 5-HT2AR and reduces platelet activation.
These findings suggest a novel mechanism where prolonged use of SSRI medications results in reduced platelet aggregation. This provides useful insight into the effects of SSRIs and supports findings that drugs targeting the serotonin receptor may be used to reduce recurrent thrombosis by blocking platelet activation.
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