By-product of Teflon manufacture used to generate compounds for medicinal, agrichemical and materials sciences
Efficient ways of introducing CF3 groups into target molecules are being sought. The nucleophilic trifluoromethylation of carbonyl compounds using a Ruppert–Prakash reagent – (trifluoromethyl)trimethylsilane – is a well-explored strategy. But, (trifluoromethyl)trimethylsilane is expensive to prepare and is prepared from ozone-depleting bromotrifluoromethane. Fluoroform – a by-product of Teflon manufacture – has emerged as a potential environmentally benign alternative to (trifluoromethyl) trimethylsilane. It is also non-toxic, cheap and available in large quantities.
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