Wrapping up hydrophobic hydration
Studied in detail, the embedding of hydrophobic molecules in water looks quite different than previously assumed
© Marie-Pierre Gaigeot
These new findings were published by the team headed by Professor Martina Havenith, Chair of Physical Chemistry II and Speaker of the Ruhr Explores Solvation Cluster of Excellence at Ruhr-Universität Bochum (RUB) in The Journal of Physical Chemistry Letters on 18 June 2020.
Insights by THz spectroscopy and simulations
In their study, the researchers investigated the hydrogen bond network around the hydrophobic solvated alcohol tert-butanol, as researchers use alcohols as a prototype models for hydrophobic molecules. The team combined results from terahertz (THz) spectroscopy and simulations.
In THz spectroscopy, researchers measure the absorption of THz radiation in a sample. The absorption spectrum provides a fingerprint of the water network.
A thin layer
In their study they obtained a detailed picture of the water layers surrounding the molecule. “We refer to the innermost layer as ‘HB-wrap’, where HB stands for water hydrogen bond,” explains Martina Havenith. The top layer is called ‘HB-hydration2bulk’ as it described the interface to the bulk water. Combined, both layers of the coating are sometimes no thicker than a single layer of water molecules. “Occasionally, a single water molecule may be part of both layers,” says Havenith.
Inner layer is longer stable
When the temperature is increased, the outer layer melts first, the HP-wrap layer remains longer intact. “The inner layer has also less freedom to form distinct configurations due to the hydrophobicity of the solute,” elaborates the researcher. “As individual water molecules must always turn away from the alcohol, they form a two-dimensional, loose network.” Water molecules in the outer layer have more freedom to move and therefore also more possibilities to connect with other water molecules; researchers refer to this phenomenon as greater entropy.
This type of interaction is relevant for the folding processes of proteins as well as biomolecular recognition between a drug and its target molecule. Understanding the role of water plays a crucial role in the process.
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Investigation with spectroscopy gives us unique insights into the composition and structure of materials. From UV-Vis spectroscopy to infrared and Raman spectroscopy to fluorescence and atomic absorption spectroscopy, spectroscopy offers us a wide range of analytical techniques to precisely characterize substances. Immerse yourself in the fascinating world of spectroscopy!
Topic World Spectroscopy
Investigation with spectroscopy gives us unique insights into the composition and structure of materials. From UV-Vis spectroscopy to infrared and Raman spectroscopy to fluorescence and atomic absorption spectroscopy, spectroscopy offers us a wide range of analytical techniques to precisely characterize substances. Immerse yourself in the fascinating world of spectroscopy!