Annulation made easy
Chinese scientists report a new and economical route to polycyclic aromatic compounds
Transition metal-catalysed annulation reactions have previously been reported but suffer from several disadvantages such as harsh conditions, inaccessible substrates and sometimes expensive catalysts. The route developed by Li and co-workers is more atom economical overall, and uses a cheap iron-catalyst and starting materials that are easily prepared.
Li believes the mechanism of this reaction involves a Diels-Alder process, but points out that this will be the next challenge for chemists in this field; trapping the iron intermediates of the reaction in order to define the mechanism of the process.
Original publication: Zhi-Qiang Wang, Chem. Commun., 2009.
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Topic world Synthesis
Chemical synthesis is at the heart of modern chemistry and enables the targeted production of molecules with specific properties. By combining starting materials in defined reaction conditions, chemists can create a wide range of compounds, from simple molecules to complex active ingredients.
Topic world Synthesis
Chemical synthesis is at the heart of modern chemistry and enables the targeted production of molecules with specific properties. By combining starting materials in defined reaction conditions, chemists can create a wide range of compounds, from simple molecules to complex active ingredients.