Ensuring reproducibility in process chemistry with automated sampling
Learn how to minimize human error, ensure sample integrity, and streamline your chemical reactions
Inconsistent sampling can lead to incorrect conclusions about reaction progress, yield, and quality. Therefore, accurate and reproducible sampling is crucial, especially when scaling up chemical processes.
This application note is based on research carried out by a team of scientists at Pfizer. They evaluated the sampling reproducibility of the ReactALL system with SmartCap technology. Using diphenyl ether in acetonitrile and a mixture of diphenyl ether and sodium tosylate in toluene, the results demonstrate consistent and reliable sampling performance, comparable to manual sampling. Furthermore, the results were achieved with minimal variability in both homogeneous and heterogeneous mixtures, as reported by Hawkins et al. (Org. Process Res. Dev. 2024, 28, 9, 3637–3644)
What can you learn from this application note:
- Understand the benefits of automated sampling in improving precision and minimizing errors.
- Learn how ReactALL’s SmartCap technology ensures consistent and representative sampling for both homogeneous and heterogeneous reactions.
- Explore how automated quenching and dilution capabilities streamline workflows and ensure reliable sample analysis.
Download white paper now
Ensuring reproducibility in process chemistry with automated sampling
Learn how to minimize human error, ensure sample integrity, and streamline your chemical reactions
White Paper classification
White papers on related topics
Products on related topics
Manufacturers of similar products
You may also be interested in these white papers
See the theme worlds for related content
Topic world Synthesis
Chemical synthesis is at the heart of modern chemistry and enables the targeted production of molecules with specific properties. By combining starting materials in defined reaction conditions, chemists can create a wide range of compounds, from simple molecules to complex active ingredients.
Topic world Synthesis
Chemical synthesis is at the heart of modern chemistry and enables the targeted production of molecules with specific properties. By combining starting materials in defined reaction conditions, chemists can create a wide range of compounds, from simple molecules to complex active ingredients.