Breaking bonds to form bonds: Rethinking the Chemistry of Cations

New chemical reaction with potential applications in medicinal chemistry

22-May-2024 - A team of chemists from the University of Vienna, led by Nuno Maulide, has achieved a significant breakthrough in the field of chemical synthesis, developing a novel method for manipulating carbon-hydrogen bonds. This groundbreaking discovery provides new insights into the molecular interactions ...

Art with DNA – Digitally creating 16 million colors by chemistry

Previous limitation to 256 colors far exceeded

18-Oct-2023 - The DNA double helix is composed of two DNA molecules whose sequences are complementary to each other. The stability of the duplex can be fine-tuned in the lab by controlling the amount and location of imperfect complementary sequences. Fluorescent markers bound to one of the matching DNA strands ...

A molecular "Trojan Horse"

28-Aug-2019 - The research group of Nuno Maulide from the Faculty of Chemistry of the University of Vienna has, in cooperation with the Research Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences, achieved the synthesis of a potential immunosuppressive agent by modification of a naturally ...

When changing one atom makes molecules better

A method to replace hydrogen with fluorine in organic molecules makes drugs more effective

07-Mar-2019 - The development and improvement of pharmaceuticals plays the central role in the ongoing battle against human disease. Organic synthesis is the field that enables these developments as it offers the toolbox to diversify chemical structures. The group of Nuno Maulide, recently named the Scientist ...

Never say never in the nano-world

02-Apr-2014 - Objects with sizes in the nanometer range, such as the molecular building blocks of living cells or nanotechnological devices, are continuously exposed to random collisions with surrounding molecules. In such fluctuating environments the fundamental laws of thermodynamics that govern our ...