Anionic Nickel

Nickel-catalyzed cross-coupling of aromatic ethers proceeds via a nickelate anion

26-Oct-2021 - Metal catalysts are widely used in the production of drugs, dyes, adhesives, and plastics. Researchers have now discovered an intriguing property of nickel as a catalyst: it is able to catalyze the coupling of aromatic hydrocarbons in its anionic form, the nickelate ion. In this form, the two ...

Chemist developed a green catalyst for pharmaceutical and industrial chemistry

Catalyst based on a substance that comes from plant waste

08-Sep-2020 - Many production facilities (e.g. plastic manufacturers, pharma companies, and others) use nanocatalysts that contain palladium--an expensive component that is not sustainably produced. A chemist from RUDN University found a way to reduce palladium consumption and to make its manufacture more ...

Put into the right light - Reproducible and sustainable coupling reactions

Improved methods for coupling reactions with light by targeted control of the catalyst activity

09-Jul-2020 - A team of researchers reports in the journal Nature Catalysis that sustainable carbon-nitrogen cross-couplings can be performed using simple nickel salts, carbon nitrides and light. The chemists study the use of cost-effective and reproducible semiconductors as photocatalysts in coupling ...

Making Puffer Fish Toxin in a Flask

Total synthesis of tetrodotoxin

10-Mar-2020 - In Japan, puffer fish is considered a delicacy, but the tickle to the taste buds comes with a tickle to the nerves: fugu contains tetrodotoxin, a strong nerve toxin. In low doses, tetrodotoxin is shown in clinical trials to be a replacement for opioids for relieving cancer related pain. In the ...

Boosting solid state chemical reactions

13-Feb-2019 - Adding olefin enables efficient solvent-free cross-coupling reactions, leading to environmentally friendly syntheses of a wide range of organic materials. A cross coupling reaction is typically performed in an organic solvent and leads to the production of a large amount of solvent waste, which ...

Best of both worlds: Combining two skeleton-building chemical reactions

13-Aug-2018 - Scripps Research scientists have developed a powerful new strategy for synthesizing molecular skeletons of chemicals used in drugs and other important products, a technique that provides unprecedented flexibility and control over chemical synthesis. The method, which combines two chemical ...

Synthesis of medicinally privileged heterocycles through dielectric heating

10-Mar-2017 - Heterocyclic compounds are enormously crucial in various industries including food, agricultural, cosmetics and pharmaceuticals. Heterocyclic pharmacophores are one of the main chemical components in drug discovery research. A report in 2013 claims that four out of six and nine out of twenty one ...

One-pot synthesis towards sulfur-based organic semiconductors

A short and simple synthetic route for thiophene-fused aromatic compounds

11-Oct-2016 - Dr. Lingkui Meng, Dr. Yasutomo Segawa, Professor Kenichiro Itami of the JST-ERATO Itami Molecular Nanocarbon Project, Institute of Transformative Bio-Molecules (ITbM) of Nagoya University and Integrated Research Consortium on Chemical Sciences, and their colleagues have reported on the ...

New reaction turns feedstock chemical into versatile, chiral building block

30-Mar-2016 - Researchers in the Doyle lab at Princeton have developed a direct cross-coupling reaction to produce nitrogen-containing compounds called 1,2-dihydropyridines, versatile building blocks that are highly useful in pharmaceutical research. The reaction employs a chiral nickel catalyst and an ...

Transition metal catalyst prompts 'conjunctive' cross-coupling reaction

05-Jan-2016 - By employing a third reactant, researchers at Boston College have developed a new type of 'cross coupling' chemical reaction, building on a Nobel Prize-winning technique that is one of the most sophisticated tools available to research chemists. A key component of that novel approach - known as ...