Marine natural product synthesis
Neopeltolide is a structurally complex marine natural product that potently inhibits the growth of cancer cell lines. It is in very limited supply from its natural sponge source so an efficient synthesis is essential to permit more extensive biological studies.
Whilst this compound has been synthesized before by other research groups, Paterson explains that ‘the beauty of this route is that it uses catalytic asymmetric methods for introducing most of the stereocentres, where the tetrahydropyran ring system is established with excellent control over the stereochemistry by a Jacobsen hetero Diels-Alder reaction.’
Original article: Ian Paterson et al., Chem. Commun., 2008.
Other news from the department science
Get the chemical industry in your inbox
From now on, don't miss a thing: Our newsletter for the chemical industry, analytics, lab technology and process engineering brings you up to date every Tuesday and Thursday. The latest industry news, product highlights and innovations - compact and easy to understand in your inbox. Researched by us so you don't have to.
Most read news
More news from our other portals
See the theme worlds for related content
Topic world Synthesis
Chemical synthesis is at the heart of modern chemistry and enables the targeted production of molecules with specific properties. By combining starting materials in defined reaction conditions, chemists can create a wide range of compounds, from simple molecules to complex active ingredients.
Topic world Synthesis
Chemical synthesis is at the heart of modern chemistry and enables the targeted production of molecules with specific properties. By combining starting materials in defined reaction conditions, chemists can create a wide range of compounds, from simple molecules to complex active ingredients.