Marine natural product synthesis
Neopeltolide is a structurally complex marine natural product that potently inhibits the growth of cancer cell lines. It is in very limited supply from its natural sponge source so an efficient synthesis is essential to permit more extensive biological studies.
Whilst this compound has been synthesized before by other research groups, Paterson explains that ‘the beauty of this route is that it uses catalytic asymmetric methods for introducing most of the stereocentres, where the tetrahydropyran ring system is established with excellent control over the stereochemistry by a Jacobsen hetero Diels-Alder reaction.’
Original article: Ian Paterson et al., Chem. Commun., 2008.
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Topic world Synthesis
Chemical synthesis is at the heart of modern chemistry and enables the targeted production of molecules with specific properties. By combining starting materials in defined reaction conditions, chemists can create a wide range of compounds, from simple molecules to complex active ingredients.
Topic world Synthesis
Chemical synthesis is at the heart of modern chemistry and enables the targeted production of molecules with specific properties. By combining starting materials in defined reaction conditions, chemists can create a wide range of compounds, from simple molecules to complex active ingredients.