New Online Analysis Optimizes Drying Processes in the Pharmaceutical Industry
drying processes are an important part of the production of intermediate and end products in the pharmaceutical industry. In addition to the determination of a suitable temperature and pressure, the automatic recognition of the production end point is a crucial factor when optimizing processes.
Through the use of online analysis with a mass spectrometer (MS), the end point of the drying process can be determined and documented with precision and without the need for costly and time-consuming manual sampling. In the USA, for example, the FDA's (Food and Drug Administration) PAT initiative calls for the closest possible supervision and coordination of the entire production process in the manufacture of pharmaceutical products. The implementation of this model can be of great significance for the international pharmaceutical industry.
The end of the drying process is reached at different times depending on the method of drying and the size and character of the batch. As a rule the end point is determined by way of manual samplings and off-line so-called loss of drying tests in the laboratory. In contrast, the online analysis using an MS provides an extremely fast and automated solution. The exhaust air, and consequently the drying progress, is constantly monitored and documented. This is possible with an MS both under normal pressure and in the case of vacuum drying at a pressure of 1 to 1200 mbar. The mass spectrometric online analysis can also be used to establish optimal drying temperature and pressure. Process optimisation offers advantages in terms of more efficient use of plants and facilities as well as provides increased consistency in the product quality. Moreover, the resulting savings in time and energy also mean greater cost-effectiveness.
InProcess Instruments have recently published a report , in which they document these applications for their quadrupole mass spectrometers. The report can be downloaded from their internet site.
Other news from the department research and development
These products might interest you
isoprime precisION by Elementar Analysensysteme
isoprime precisION stable isotope ratio mass spectrometer
The most flexible, yet powerful isotope ratio mass spectrometer ever created
HPR-20 OEMS, Online Electrochemical Mass Spectrometer by Hiden Analytical
Online monitoring and quantification of evolved gases and vapours from electrochemical processes
A complete gas analysis solution, designed to integrate seamlessly with electrochemical applications
PlasmaQuant MS Elite by Analytik Jena
LC-ICP-MS Is the Key to the World of Elemental Species
Highest Sensitivity and Lowest Detection Limits with PlasmaQuant MS Series and PQ LC
IonTamer ToF MS by Spacetek Technology
IonTamer instruments are time-of-flight residual gas analysers (TOF-RGA) for the analysis of gases
Compact Time-of-flight residual gas analyzer (TOF-RGA) for process analysis
NexION® 5000 by PerkinElmer
NexION 5000 Multi-Quadrupole ICP Mass Spectrometer
NexION 5000 Multi-Quadrupole ICP Mass Spectrometer
HPR-20 R&D by Hiden Analytical
A specialist benchtop triple filter mass spectrometer for the monitoring of evolved gases & vapours
Providing improved resolution & abundance sensitivity with an ultimate detection limit of 5 ppb sub
CATLAB Catalysis and Thermal Analysis by Hiden Analytical
A system for catalyst characterisation, kinetic and thermodynamic measurements
Integrated Microreactor-Mass Spectrometer for Reaction Testing, TPD/R/O and Pulse Chemisorption.
Xevo TQ Absolute by Waters
A new Tandem Quadrupole Mass Spectrometer for Quantification with Absolute power
Absolute performance, efficiency, productivity, and confidence for your most challenging compounds
BIOS ANALYTIQUE - Soluciones de Renting y Leasing para laboratorios by Bios Analytique
Specialists in the rental and leasing of scientific equipment for laboratories throughout Europe
Whether you have an unexpected requirement or limited budget, we have the perfect solution for you
iCAP RQ single Quadrupole ICP-MS by Thermo Fisher Scientific
Robust ICP-MS with ease of use and high productivity for routine analysis
A complete multi-element analysis solution for your high-throughput routine laboratory
iCAP TQ Triple Quadrupole ICP-MS by Thermo Fisher Scientific
Overcome unexpected interferences, reduce detection limits and improve data quality
Ultralow limits of detection with simplicity - even for the most challenging analytical applications
expression® Compact Mass Spectrometer by Advion Interchim Scientific
Mass Spectrometry for Chemists: Fast, Easy, Prep-Free Reaction Monitoring at the Bench
Featuring a variety of sample introduction techniques that also allow TLC/MS & direct probe analysis
JEOL JMS-T2000GC AccuTOF GC-Alpha Time-of-Flight Mass Spectrometer by JEOL
A new era of mass spectrometry for your fast forward daily lab routine:
Welcome JEOL AccuTOF GC-Alpha
Stop wrong hypotheses and uneconomic loops! Precise data without compromise is now.
Thermo Scientific TSQ Triple Quadrupole Mass Spectrometry Systems by Thermo Fisher Scientific
Confident quantitation with triple quadrupole LC-MS systems
Mass Spectrometry Systems
TSQ 9610 GC-MS/MS by Thermo Fisher Scientific
TSQ 9610 GC-MS/MS for superb sensitivity and selectivity with outstanding reliable productivity
Eliminate unnecessary, unplanned instrument downtime, save helium and maximize productivity
Orbitrap Exploris GC Mass Spectrometer by Thermo Fisher Scientific
Orbitrap Exploris GC-MS simplifies operations and offers new opportunities for analytical testing
Keep pace with changing demands, maximize system uptime, and expand laboratory capability.
Get the chemical industry in your inbox
From now on, don't miss a thing: Our newsletter for the chemical industry, analytics, lab technology and process engineering brings you up to date every Tuesday and Thursday. The latest industry news, product highlights and innovations - compact and easy to understand in your inbox. Researched by us so you don't have to.
Most read news
More news from our other portals
See the theme worlds for related content
Topic World Spectroscopy
Investigation with spectroscopy gives us unique insights into the composition and structure of materials. From UV-Vis spectroscopy to infrared and Raman spectroscopy to fluorescence and atomic absorption spectroscopy, spectroscopy offers us a wide range of analytical techniques to precisely characterize substances. Immerse yourself in the fascinating world of spectroscopy!
Topic World Spectroscopy
Investigation with spectroscopy gives us unique insights into the composition and structure of materials. From UV-Vis spectroscopy to infrared and Raman spectroscopy to fluorescence and atomic absorption spectroscopy, spectroscopy offers us a wide range of analytical techniques to precisely characterize substances. Immerse yourself in the fascinating world of spectroscopy!
