Geneprot And Bruker Daltonics Plan Large-Scale Deployment Of Maldi-TOF/TOF Mass Spectrometers For High-Throughput Proteomics
GeneProt™, Inc. and Bruker Daltonics Inc. (NASDAQ: BDAL) today announced an agreement to deploy novel MALDI-TOF/TOF mass spectrometry technology at GeneProt's new U.S. proteomics facility in North Brunswick, N.J. Under the agreement, GeneProt will initially purchase a total of six UltraFlex™ TOF/TOF systems for its U.S. facility and an additional UltraFlex TOF/TOF system for its European proteomics discovery and production center. GeneProt's U.S. facility is expected to be completed in the second quarter of 2002.
MALDI-TOF/TOF technology dramatically increases the throughput, sensitivity and specificity of proteomic studies. It provides traditional MALDI-TOF peptide mass finger-printing for protein identification, and then immediately, on the same target and without further sample work-up, provides detailed tandem mass spectrometry (MS/MS) information for unambiguous identification and the characterization of proteins.
"We are moving very rapidly to utilize cutting-edge TOF/TOF technology in our proteomic drug discovery programs in the near future," said Cédric Loiret-Bernal, M.D., GeneProt's Chief Executive Officer. "Our scientific experts have carefully analyzed and tested the available MALDI-TOF/TOF systems, and we have come to the conclusion that the UltraFlex TOF/TOF excels in its performance. GeneProt is excited to be one of the first companies to make the advanced Bruker Daltonics MALDI-TOF/TOF systems available to our current and future pharmaceutical partners in an industrial-scale proteomics facility.
The UltraFlex TOF/TOF was introduced by Bruker Daltonics in July 2001, and due to its unique design it excels in sensitivity and throughput, as well as the information content provided. From a few femtomoles of a protein digest, the UltraFlex TOF/TOF will typically provide MS/MS characterization of five to ten tryptic peptides in less than 3 minutes, in what traditionally has taken more than 30 minutes by LC/MS/MS. The UltraFlex uses microtitre-sized AnchorChip™ targets, which are compatible with many industry-standard robots for protein digestion, MALDI target preparation, and robotic delivery of targets to the UltraFlex for unattended, uninterrupted operation. In addition, the UltraFlex TOF/TOF data is easily interpreted by existing bioinformatics software, making the integration of high-quality TOF/TOF data into present proteomics paradigms robust and automated.
Frank Laukien, Ph.D., President and CEO of Bruker Daltonics, commented: "We are very pleased that, after careful evaluation, GeneProt has decided to utilize our UltraFlex TOF/TOF systems for their new U.S. facility. It will enhance their already very impressive technology platform for proteomics, and we believe that it will further strengthen GeneProt's position as a leading proteomics company."
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