Geneprot And Bruker Daltonics Plan Large-Scale Deployment Of Maldi-TOF/TOF Mass Spectrometers For High-Throughput Proteomics
GeneProt™, Inc. and Bruker Daltonics Inc. (NASDAQ: BDAL) today announced an agreement to deploy novel MALDI-TOF/TOF mass spectrometry technology at GeneProt's new U.S. proteomics facility in North Brunswick, N.J. Under the agreement, GeneProt will initially purchase a total of six UltraFlex™ TOF/TOF systems for its U.S. facility and an additional UltraFlex TOF/TOF system for its European proteomics discovery and production center. GeneProt's U.S. facility is expected to be completed in the second quarter of 2002.
MALDI-TOF/TOF technology dramatically increases the throughput, sensitivity and specificity of proteomic studies. It provides traditional MALDI-TOF peptide mass finger-printing for protein identification, and then immediately, on the same target and without further sample work-up, provides detailed tandem mass spectrometry (MS/MS) information for unambiguous identification and the characterization of proteins.
"We are moving very rapidly to utilize cutting-edge TOF/TOF technology in our proteomic drug discovery programs in the near future," said Cédric Loiret-Bernal, M.D., GeneProt's Chief Executive Officer. "Our scientific experts have carefully analyzed and tested the available MALDI-TOF/TOF systems, and we have come to the conclusion that the UltraFlex TOF/TOF excels in its performance. GeneProt is excited to be one of the first companies to make the advanced Bruker Daltonics MALDI-TOF/TOF systems available to our current and future pharmaceutical partners in an industrial-scale proteomics facility.
The UltraFlex TOF/TOF was introduced by Bruker Daltonics in July 2001, and due to its unique design it excels in sensitivity and throughput, as well as the information content provided. From a few femtomoles of a protein digest, the UltraFlex TOF/TOF will typically provide MS/MS characterization of five to ten tryptic peptides in less than 3 minutes, in what traditionally has taken more than 30 minutes by LC/MS/MS. The UltraFlex uses microtitre-sized AnchorChip™ targets, which are compatible with many industry-standard robots for protein digestion, MALDI target preparation, and robotic delivery of targets to the UltraFlex for unattended, uninterrupted operation. In addition, the UltraFlex TOF/TOF data is easily interpreted by existing bioinformatics software, making the integration of high-quality TOF/TOF data into present proteomics paradigms robust and automated.
Frank Laukien, Ph.D., President and CEO of Bruker Daltonics, commented: "We are very pleased that, after careful evaluation, GeneProt has decided to utilize our UltraFlex TOF/TOF systems for their new U.S. facility. It will enhance their already very impressive technology platform for proteomics, and we believe that it will further strengthen GeneProt's position as a leading proteomics company."
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Mass spectrometry enables us to detect and identify molecules and reveal their structure. Whether in chemistry, biochemistry or forensics - mass spectrometry opens up unexpected insights into the composition of our world. Immerse yourself in the fascinating world of mass spectrometry!
Topic World Mass Spectrometry
Mass spectrometry enables us to detect and identify molecules and reveal their structure. Whether in chemistry, biochemistry or forensics - mass spectrometry opens up unexpected insights into the composition of our world. Immerse yourself in the fascinating world of mass spectrometry!