ACCELRYS DELIVERS ANNOTATIONS OF 89% OF HUMAN PROTEOME TO CONSORTIUM MEMBERS

24-Aug-2001

These new annotations effectively transform once-indecipherable sequence data into thousands of potential new drug targets awaiting further experimental validation. The new annotations are part of the AtlasStore database that is delivered exclusively to members of Accelrys’ Functional Genomics Consortium.

GeneAtlas, Accelrys’ automated high throughput pipeline of analysis and annotation tools, has functionally annotated 89% of the more than 29,000 predicted Open Reading Frames (ORFs) of the human genome deposited in the Ensembl database. The automated pipeline produced 3D protein structures for more than half of the ORFs, while the remaining sequences were found to possess homology to known sequences or chemically similar active sites from which an assignment of function was made.

“The set of annotations achieved by GeneAtlas represents a significant increase over what is available in the public domain, or what can be achieved using public domain technologies,” commented Dr. Scott Kahn, Senior Vice President of Life Sciences at Accelrys. “The consolidation of sequence analysis and 3D structural analysis technologies into a single integrated target discovery platform raises the standard for the amount of the human genome that can be annotated – the diverse analyses provide an internal cross validation of the annotations that imply a higher level of accuracy then previously available. These newly annotated proteins provide numerous opportunities for the next generation of drug targets, and for greater insights into the effects of genetic variations on the efficacy of the drugs that will be discovered.”

https://www.chemeurope.com/en/news/4436/accelrys-delivers-annotations-of-89-of-human-proteome-to-consortium-members.html