Pharmaprojects Launches new Searchable Drug Target and Lipinski Fields

16-Aug-2004

Pharmaprojects, the world's leading source of business-critical intelligence on drugs in global R&D, is pleased to announce that Monday 16th August will be the launch date of Pharmaprojects Version 5.1 for the Web, which will enable our customers to search the Pharmaprojects database by protein drug targets and Lipinski's `Rule of 5' parameters.

Search by protein drug targets

Our expert team of scientific editors has researched protein drug targets for all 32,000+ drug profiles on Pharmaprojects. As a result, we have identified over 1,300 proteins as drug targets (including 1,200 unique human proteins) for drugs that have been in R&D since 1980, bringing you a target searching facility with unrivalled detail and comprehensiveness. Precise drug targets have been assigned to over 43% of drugs on the database, giving a highly detailed picture of drug development strategies pursued over more than two decades.

Pharmaprojects Version 5.1 enables customers to search by complete or partial target name or LocusLink/Entrez Gene ID number, for easy identification of all drugs acting on a target of interest. The target name picklist, which includes all synonyms and gene codes by which each target is known, has been enhanced considerably by Pharmaprojects' editors to resolve inconsistencies and ambiguities in naming, to facilitate easier searching. In addition, it is now possible to access specific Entrez Gene target profiles and a wealth of further information in the public databases, by simply clicking a hyperlink in the Pharmaprojects drug profile.

"For any company tracking pharmaceutical R&D, or any company developing drugs against novel targets, this will be an invaluable tool," says Ian Lloyd, Managing Editor of Pharmaprojects. "Using this new feature, you can quickly check for target novelty, see who else is working on similar targets and for what indications, pick up the hottest licensing opportunities, spot drugs suitable for reprofiling, and avoid potential problem areas, all at the click of a button."

New chemical search fields- Lipinski parameters and rotatable bonds

With Pharmaprojects Version 5.1, it is also now possible to search across our 14,000+ chemical structures for compounds that obey/disobey Lipinski's `Rule of 5'. This can be used to predict which compounds are most likely to be orally bioavailable. In addition, clients have the ability to search the database for compounds having a certain number of rotatable bonds, which can be used to predict membrane permeability and oral bioavailability.

With the new protein target data and chemical data fields, we now have 73 searchable fields - giving our customers even greater search flexibility and millions of possible search strategies.

Pharmaprojects Version 5.1 also features enhanced text searching functionality, and it is now possible to search by using phrases, strings, wildcards or truncation. Customers will also benefit from the software's improved speed and from our weekly updates.

https://www.chemeurope.com/en/news/39102/pharmaprojects-launches-new-searchable-drug-target-and-lipinski-fields.html