Agilent Technologies announces highly sensitive method for analyzing herbicide amitrol in water
Amitrol is used both as an herbicide and photographic chemical. A suspected carcinogen, it has been cited as a hazardous substance by the EPA and National Institute for Occupational Safety and Health.
Sub-parts-per-billion analysis of amitrol in water raises two challenges: Amitrol's low molecular weight does not produce a specific, recognizable ion in mass spectrometry, and this highly soluble compound is difficult to recover in a water sample. Both challenges can be solved by in situ derivatization with hexylchloroformate.
Agilent chemists used this derivatization technique, solid phase extraction and liquid chromatography/mass selective detection to analyze amitrol with minimum sample preparation. The scientists performed the analysis on an Agilent 1100 Series LC/MSD system operated in atmospheric pressure chemical ionization mode with selective ion monitoring and large volume injection (100 uL). This method characterized amitrol at the ppb level (0.02 ug/L).
The repeatability of the analysis was verified by quantifying six standard solutions (50 mL each) at 0.05 ppb amitrol and 0.5 ppb internal standard. The complete derivatization and extraction procedure gave a relative standard deviation of just 6.5 percent.
Other news from the department research and development
Get the chemical industry in your inbox
From now on, don't miss a thing: Our newsletter for the chemical industry, analytics, lab technology and process engineering brings you up to date every Tuesday and Thursday. The latest industry news, product highlights and innovations - compact and easy to understand in your inbox. Researched by us so you don't have to.
Most read news
More news from our other portals
See the theme worlds for related content
Topic world Extraction
Extraction is a fundamental process in the chemical laboratory that enables specific components to be isolated and concentrated from a mixture. Whether it's extracting active ingredients from natural products, removing impurities from synthesis products, or preparing analytical samples, extraction is a key step in achieving precise and efficient results in chemical research and analysis.
Topic world Extraction
Extraction is a fundamental process in the chemical laboratory that enables specific components to be isolated and concentrated from a mixture. Whether it's extracting active ingredients from natural products, removing impurities from synthesis products, or preparing analytical samples, extraction is a key step in achieving precise and efficient results in chemical research and analysis.
Topic World Mass Spectrometry
Mass spectrometry enables us to detect and identify molecules and reveal their structure. Whether in chemistry, biochemistry or forensics - mass spectrometry opens up unexpected insights into the composition of our world. Immerse yourself in the fascinating world of mass spectrometry!
Topic World Mass Spectrometry
Mass spectrometry enables us to detect and identify molecules and reveal their structure. Whether in chemistry, biochemistry or forensics - mass spectrometry opens up unexpected insights into the composition of our world. Immerse yourself in the fascinating world of mass spectrometry!
Topic World Chromatography
Chromatography enables us to separate, identify and thus understand complex substances. Whether in the food industry, pharmaceutical research or environmental analysis - chromatography opens up a treasure trove of information about the composition and quality of our samples. Discover the fascinating world of chromatography!
Topic World Chromatography
Chromatography enables us to separate, identify and thus understand complex substances. Whether in the food industry, pharmaceutical research or environmental analysis - chromatography opens up a treasure trove of information about the composition and quality of our samples. Discover the fascinating world of chromatography!