More effective than vitamin E: a new class of antioxidants
The trouble with the peroxidation of lipids is that it is a chain reaction. In the first step, an oxygen radical -- a molecule with an unpaired electron on an oxygen atom, removes a hydrogen atom from a lipid. This leaves behind a lipid radical, which has an unpaired electron on a carbon atom, which reacts with an oxygen molecule to form a lipid peroxyl radical. This is an oxygen radical that can then attack another lipid in turn -- in order to steal a hydrogen atom -- resulting in yet another lipid radical.The vicious circle starts all over again and is difficult to stop. This is where antioxidants like alpha-tocopherol come into the picture; they intercept the lipid peroxyl radicals. Radical scavengers like tocopherol are phenols, they consist of a six-membered aromatic carbon ring with an attached oxygen atom, and this oxygen atom carries a hydrogen atom (an OH group). This hydrogen atom is stripped away by the peroxyl radical. In contrast to the lipid radicals, the resulting phenolic radical is relatively unreactive, and the chain reaction stops. In order to find an even better radical interceptor, the chemists searched for a phenolic compound, whose OH group gives up its hydrogen atom more easily than vitamin E. However, most of these super radical scavengers are much to readily attacked by oxygen in the air to be useful.
Computer simulations enabled Pratt and his co-workers to develop a new class of air-stable phenolic antioxidants. Subsequent experiments have demonstrated that two of these amino pyridinol compounds, as they are called, are particularly effective radical scavengers. They consist of a phenol ring, in which one of the carbon atoms has been replaced with a nitrogen atom. This aromatic (containing three double bonds) ring is fused with another, aliphatic (containing only single bonds) carbon ring, which also contains a nitrogen atom. "These amino pyridinols are, to the best of our knowledge, the fastest peroxyl-radical-trapping antioxidants ever reported," says Pratt.
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