Revolutionary process to create ether from esters using metal catalysts
A group of Waseda University researchers has developed a new process using palladium or nickel as a catalyst for removing carbon monoxide from esters to produce ethers. This innovation provides new opportunities for development of drugs to fight cancer, malaria and more.
This is a better way to make diaryl ether.
Waseda University
The conventional method for producing diaryl ether uses an intermolecular cross-coupling reaction of aryl halides and phenols with a copper or palladium catalyst, but high cost and concerns about disposal of potentially hazardous halogenated waste have driven demand for a better method.
In this research, a nickel or palladium catalyst with an enabling diphosphine ligand successfully removed carbon monoxide from aromatic esters to synthesize diaryl ether. Using this innovative process, diaryl ethers can be produced from over 30 different kinds of aromatic esters, allowing a choice of more inexpensive and easily obtainable materials. The present reaction can also be conducted on a gram scale with excellent yield, all of which is expected to make a significant impact on development of new pharmaceuticals.
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Topic world Synthesis
Chemical synthesis is at the heart of modern chemistry and enables the targeted production of molecules with specific properties. By combining starting materials in defined reaction conditions, chemists can create a wide range of compounds, from simple molecules to complex active ingredients.
Topic world Synthesis
Chemical synthesis is at the heart of modern chemistry and enables the targeted production of molecules with specific properties. By combining starting materials in defined reaction conditions, chemists can create a wide range of compounds, from simple molecules to complex active ingredients.
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