Nanoparticle drug reverses Parkinson's-like symptoms in rats
Rajnish Kumar Chaturvedi, Kavita Seth, Kailash Chand Gupta and colleagues from the CSIR-Indian Institute of Toxicology Research note that among other issues, people with Parkinson's lack dopamine in the brain. Dopamine is a chemical messenger that helps nerve cells communicate with each other and is involved in normal body movements. Reduced levels cause the shaking and mobility problems associated with Parkinson's. Symptoms can be relieved in animal models of the disease by infusing the compound into their brains. But researchers haven't yet figured out how to safely deliver dopamine directly to the human brain, which is protected by something called the blood-brain barrier that keeps out pathogens, as well as many medicines. Chaturvedi and Gupta's team wanted to find a way to overcome this challenge.
The researchers packaged dopamine in biodegradable nanoparticles that have been used to deliver other therapeutic drugs to the brain. The resulting nanoparticles successfully crossed the blood-brain barrier in rats, released its dopamine payload over several days and reversed the rodents' movement problems without causing side effects.
Original publication
"Trans-Blood Brain Barrier Delivery of Dopamine Loaded Nanoparticles Reverses Functional Deficits in Parkinsonian Rats"; ACS Nano 2015.
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Original publication
"Trans-Blood Brain Barrier Delivery of Dopamine Loaded Nanoparticles Reverses Functional Deficits in Parkinsonian Rats"; ACS Nano 2015.
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