Simple synthesis of heavy oxygen-labelled alcohols
Alcohols labelled with 18O are very valuable as biological probes for a variety of studies which are often limited by the availability of labelled precursors for use in the synthesis of the compounds of interest.
Scientists in Israel prepared an 18O-labelled acetonitrile complex of hypofluorous acid by simply bubbling dilute F2 through acetonitrile and 18O-labelled water. They performed a series of reactions of this complex with a variety of aliphatic and aromatic boronic acids at room temperature to produce a series of 18O-labelled alcohols within just a few minutes and in excellent yields – generally upwards of 90 per cent.
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Topic world Synthesis
Chemical synthesis is at the heart of modern chemistry and enables the targeted production of molecules with specific properties. By combining starting materials in defined reaction conditions, chemists can create a wide range of compounds, from simple molecules to complex active ingredients.
Topic world Synthesis
Chemical synthesis is at the heart of modern chemistry and enables the targeted production of molecules with specific properties. By combining starting materials in defined reaction conditions, chemists can create a wide range of compounds, from simple molecules to complex active ingredients.