New Chiral Hydrogenation Technology
Leverkusen - Bayer AG has commercialized a new chiral hydrogenation technology to meet the demand for chiral advanced intermediates and active pharmaceutical ingredients with one or more stereo-centers. The technology allows Bayer to produce chiral hydrogenation catalysts including the R and S version of Bayer's proprietary ligand Cl-MeO-BIPHEP, formally known as (R) and (S)-5,5'-Dichloro-6,6'-dimethoxy-2,2'-bis(diphenylphosphino)-1,1'-biphenyl. Cl-MeO-BIPHEP forms organometallic complexes with the transition metals ruthenium and rhodium. The ruthenium complex is an especially versatile catalyst for the efficient enantioselective hydrogenation (ee often greater than 99 percent) of CO and CC double-bonded substrates. Bayer launched the technology in late 2001 in one of its processes and is now using this ligand to perform a multi-ton enantioselective hydrogenation.
To promote Cl-MeO-BIPHEP in the international R&D community, Bayer AG has entered into agreement with Strem Chemicals, Inc. to market the ligand in research quantities. Strem, with U.S. headquarters in Newburyport, Mass., is a leading manufacturer and marketer of R&D chemicals. The company is currently selling and shipping orders for the R and S versions of Cl-MeO-BIPHEP (CAS No. 185913-98-8 and 185913-97-7).
Bayer's new synthesis allows the introduction of a wide spectrum of substituents (R-groups) in place of the phenyl group on the phosphorous. "This allows us to fine tune the catalyst more efficiently than was possible before. Previously, the racemic separation took place after the R group was attached. That required working out a separate resolution for each R group," Rudolph Hanko, head of Bayer's Fine Chemicals Business Unit, said. In addition to custom manufacturing, Bayer's Fine Chemicals Business Unit offers its customers process development services. These include finding the most suitable catalyst.
For enantioselective hydrogenation processes, complexes with Cl-MeO-BIPHEP are but one of many possible catalysts. Using fast screening technology, Bayer can quickly and efficiently find the optimal catalyst and reaction conditions. In addition to chiral hydrogenation, Bayer offers its customers access to other advanced chiral technologies. These including Simulated Moving Bed chromatography, crystallization-induced resolution, enzymatic conversion and stereo-specific synthesis.
Other news from the department science
![[Fe]-hydrogenase catalysis visualized using para-hydrogen-enhanced nuclear magnetic resonance spectroscopy](https://img.chemie.de/Portal/News/675fd46b9b54f_sBuG8s4sS.png?tr=w-712,h-534,cm-extract,x-0,y-16:n-xl)
These products might interest you
AZURA Purifier + LH 2.1 by KNAUER
Preparative Liquid Chromatography - New platform for more throughput
Save time and improve reproducibility during purification
Pharmaceutical Substances by Thieme Verlag
Look up Industrial Syntheses of 2,600 APIs
Your tool for Syntheses, Patents and Applications – Pharmaceutical Substances
Get the chemical industry in your inbox
From now on, don't miss a thing: Our newsletter for the chemical industry, analytics, lab technology and process engineering brings you up to date every Tuesday and Thursday. The latest industry news, product highlights and innovations - compact and easy to understand in your inbox. Researched by us so you don't have to.
Most read news
More news from our other portals
See the theme worlds for related content
Topic world Synthesis
Chemical synthesis is at the heart of modern chemistry and enables the targeted production of molecules with specific properties. By combining starting materials in defined reaction conditions, chemists can create a wide range of compounds, from simple molecules to complex active ingredients.
Topic world Synthesis
Chemical synthesis is at the heart of modern chemistry and enables the targeted production of molecules with specific properties. By combining starting materials in defined reaction conditions, chemists can create a wide range of compounds, from simple molecules to complex active ingredients.
Topic World Chromatography
Chromatography enables us to separate, identify and thus understand complex substances. Whether in the food industry, pharmaceutical research or environmental analysis - chromatography opens up a treasure trove of information about the composition and quality of our samples. Discover the fascinating world of chromatography!
Topic World Chromatography
Chromatography enables us to separate, identify and thus understand complex substances. Whether in the food industry, pharmaceutical research or environmental analysis - chromatography opens up a treasure trove of information about the composition and quality of our samples. Discover the fascinating world of chromatography!
