Speed up your NMR data acquisition by using DTPA-chelated lanthanides as relaxation agents
Now, scientists in the UK show that DTPA(diethylene triamine pentacetic acid)-chelated lanthanides can be used as spin-lattice relaxation T1-shortening agents of nuclear spins, to expedite NMR data. Differential effects are seen with different lanthanides, with holmium and dysprosium causing the most relaxation, while gadolinium is ineffective at temperatures of 20 K and below.
Reducing the T1 values of the relevant nuclei increases the rate at which data can be acquired, and this new method is hoped to have applications in routine chemical analysis, as well as in selected tissue metabolism studies that require only coarse spatial localization.
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