Varian, Inc.'s New LC-NMR-MS System Helps Pharmaceutical Researchers Develop Safer, More Effective Drugs
Instrument Critical for Increasingly Important Field of "Metabonomics"
PALO ALTO, Calif., Varian, Inc. today introduced its LC-NMR-MS system, a new integrated scientific instrument geared for the latest challenges facing drug discovery and development laboratories. Combining three Varian core technologies -- liquid chromatography (LC), nuclear magnetic resonance (NMR) and mass spectrometry (MS) -- results in a powerful system that can more easily separate, identify and quantify molecules, such as metabolites, produced through biological processes.
The study of metabolites is of great importance to pharmaceutical researchers, particularly those associated with ADME (absorption, distribution, metabolism, excretion), toxicology and bio-availability as well as other groups developing in vitro diagnostic techniques. With the increases in sensitivity and throughput made possible over the past few years, NMR is playing a more important role in this work.
Using integrated LC-NMR-MS systems, researchers can study samples to reveal metabolite identity faster and with greater confidence than with separate analytical instrument offerings. Additionally, the U.S. FDA and other pharmaceutical regulatory bodies require that drug companies quantify and document metabolite identity.
"Many biologically relevant molecules and their bioconversion products have very similar structures and, often neither LC-MS nor LC-NMR will provide sufficient detail for a complete analysis," said Garry Rogerson, senior vice president of scientific instruments, Varian, Inc.
"By integrating three of Varian's core technologies into one coordinated system, we have developed a unit that will increase the productivity of a number of laboratories. We have maintained our trademark flexibility and high performance that will enable pharmaceutical groups to meet their challenging needs with this system," Rogerson continued.
In operation, compounds are first separated with the LC. The stream of resulting analytes eluted from the LC is split into two parallel streams that proceed to the mass spectrometer and to the NMR spectrometer. These two technologies are complementary -- mass spectrometry is both highly selective and sensitive, producing molecular weight and fragment data, while NMR is able to determine atomic connectivity. When combined, both sets of data result in more complete structural information. Obtaining both sets of data immediately with LC-NMR-MS increases the likelihood of generating an accurate structure for an unknown compound or confirming the presence of known compounds.
The Varian NMR spectrometer is renowned for its sensitivity and flexibility and is used for a variety of small molecule and proteomics applications. The Varian MS is available as a triple-quadrupole or in a single-quadrupole configuration that can be upgraded later to the triple-quadrupole analyzer. The LC-NMR-MS system is available for spectrometers ranging from 400 MHz to 800 MHz.
The system is available for delivery in September 2002.
Other news from the department
These products might interest you
Agera by HunterLab Europe
Measure color and gloss level simultaneously - in seconds
Easy-to-use colorimeter: standard-compliant, robust and precise
SPECORD PLUS by Analytik Jena
SPECORD PLUS Series - Maximum precision in UV/Vis
The modern classic guarantees the highest quality
ERASPEC by eralytics
Spectral Fuel Analysis in Seconds with ERASPEC
Fast delivery of over 40 fuel parameters at the push of a button
ZEEnit by Analytik Jena
Zeeman Technology for Maximum Sensitivity – Matching any Analytical Problem
Transverse-heated graphite furnace for optimum atomization conditions and high sample throughput
contrAA 800 by Analytik Jena
contrAA 800 Series – Atomic Absorption. Redefined
The best of classical atomic absorption and ICP-OES spectrometry are combined in the contrAA 800
PlasmaQuant 9100 by Analytik Jena
PlasmaQuant 9100 Series of ICP-OES Instruments
Reveal the Details That Matter
NANOPHOX CS by Sympatec
Particle size analysis in the nano range: Analyzing high concentrations with ease
Reliable results without time-consuming sample preparation
NEX CG II by Applied Rigaku Technologies
Elemental analysis at ppb level for exact results
INVENIO by Bruker
FT-IR spectrometer of the future: INVENIO
Freely upgradeable and configurable FT-IR spectrometer
ALPHA II by Bruker
Chemical analysis made easy: compact FT-IR system
Increase the efficiency of your routine analyses with user-friendly technology
Microspectrometer by Hamamatsu Photonics
Ultra-compact microspectrometer for versatile applications
Precise Raman, UV/VIS and NIR measurements in portable devices
2060 Raman Analyzer by Metrohm
Self-calibrating inline Raman spectrometer
Analyze solids, liquids and gases - for reproducible, accurate results in the process
novAA® 800 by Analytik Jena
The Analyzer 4 You - novAA 800-Series
The reliable all-rounder, making routine analysis efficient and cost-effective
PlasmaQuant MS Elite by Analytik Jena
LC-ICP-MS Is the Key to the World of Elemental Species
Highest Sensitivity and Lowest Detection Limits with PlasmaQuant MS Series and PQ LC
S4 T-STAR by Bruker
TXRF spectrometer: Sub-ppb detection limits & 24/7 analytics
Minimal operating costs because no gases, media or lab equipment are required
S2 PICOFOX by Bruker
Fast and precise trace element analysis on the move
TXRF technology for minimal samples and maximum efficiency
Micro-Z ULS by Rigaku
Accurately measure sulphur content in fuels: WDXRF analyser
Reliable routine analyses with 0.3 ppm detection limit and compact design
ZSX Primus IVi by Rigaku
High-precision WDXRF analysis for industrial applications
Maximum sensitivity and throughput for light elements and complex samples
SPECTRO ARCOS by SPECTRO Analytical Instruments
The inductively coupled plasma optical emission spectrometer (ICP-OES) for highest demands
The top-of-line SPECTRO ARCOS ICP-OES analyzer evolves elemental analysis to the next level
BIOS ANALYTIQUE - Soluciones de Renting y Leasing para laboratorios by Bios Analytique
Specialists in the rental and leasing of scientific equipment for laboratories throughout Europe
Whether you have an unexpected requirement or limited budget, we have the perfect solution for you
Get the chemical industry in your inbox
From now on, don't miss a thing: Our newsletter for the chemical industry, analytics, lab technology and process engineering brings you up to date every Tuesday and Thursday. The latest industry news, product highlights and innovations - compact and easy to understand in your inbox. Researched by us so you don't have to.
Most read news
More news from our other portals
See the theme worlds for related content
Topic World Spectroscopy
Investigation with spectroscopy gives us unique insights into the composition and structure of materials. From UV-Vis spectroscopy to infrared and Raman spectroscopy to fluorescence and atomic absorption spectroscopy, spectroscopy offers us a wide range of analytical techniques to precisely characterize substances. Immerse yourself in the fascinating world of spectroscopy!
Topic World Spectroscopy
Investigation with spectroscopy gives us unique insights into the composition and structure of materials. From UV-Vis spectroscopy to infrared and Raman spectroscopy to fluorescence and atomic absorption spectroscopy, spectroscopy offers us a wide range of analytical techniques to precisely characterize substances. Immerse yourself in the fascinating world of spectroscopy!
Topic World Mass Spectrometry
Mass spectrometry enables us to detect and identify molecules and reveal their structure. Whether in chemistry, biochemistry or forensics - mass spectrometry opens up unexpected insights into the composition of our world. Immerse yourself in the fascinating world of mass spectrometry!
Topic World Mass Spectrometry
Mass spectrometry enables us to detect and identify molecules and reveal their structure. Whether in chemistry, biochemistry or forensics - mass spectrometry opens up unexpected insights into the composition of our world. Immerse yourself in the fascinating world of mass spectrometry!
Topic World Chromatography
Chromatography enables us to separate, identify and thus understand complex substances. Whether in the food industry, pharmaceutical research or environmental analysis - chromatography opens up a treasure trove of information about the composition and quality of our samples. Discover the fascinating world of chromatography!
Topic World Chromatography
Chromatography enables us to separate, identify and thus understand complex substances. Whether in the food industry, pharmaceutical research or environmental analysis - chromatography opens up a treasure trove of information about the composition and quality of our samples. Discover the fascinating world of chromatography!
