Wikipedia:WikiProject Molecular and Cellular Biology/Style guidelines
This page will eventually contain a series of style guidelines for the Wikipedia:WikiProject Molecular and Cellular Biology.
It still has a long way to go.
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Additional recommended knowledge
Diagram guide
The guidelines for creating diagrams for the project can be found in the Molecular and Cellular Biology Diagram Guide.
Structures
Proteins
- Wikipedia articles about individual proteins or small protein families can be organized so as to look like Myoglobin, Gonadotropin-releasing hormone or Rubisco.
- Wikipedia articles about individual proteins or small protein families can each have a protein information box (see Myoglobin for an example).
- Each Wikipedia article about individual proteins or small protein families can be organized into one or more wikipedia category. See Whole proteome analysis for needed protein categories. See Cytoskeleton and Category:Cytoskeleton for an example.
- The main articles in each wikipedia protein category can be put into a navigation box (see the bottom of Cytoskeleton for an example).
Naming
Genes
The abbreviations of genes are according to HUGO Gene Nomenclature Committee and written in italic font style (the full names are also written in italic). It is recommended that we use abbreviations instead of the full name. Human gene names are written in capitals, for example ALDOA, INS, etc. For orthologs of human genes in other species, only the initial letter is capitalised, for example mouse Aldoa, bovine Ins, etc.
When we write about the genes this is correct - "the ALDOA gene is regulated...", "the rat gene for Aldoa is regulated..." or "ALDOA is regulated...", while this should not be allowed - "the gene ALDOA is regulated", b/c it's redundant. And if anyone starts arguing with you about it, say "Sorry, but we have a standart to follow" and redirect them to this section. -- Boris 15:32, 29 December 2005 (UTC)
Proteins
The same as with the genes, but not in italics. Thus human proteins are written like "THIS", whilst their orthologs in other species are written like "This". -- Boris 15:32, 29 December 2005 (UTC)
Templates
Infoboxes
Main article: Wikipedia:WikiProject Molecular and Cellular Biology/protbox usage
Myoglobin |
Model of helical domains in myoglobin. |
Gene code: |
HUGO code: MB |
Structure: |
molecular structure |
Recent publications: |
role in human pathologies, gene knockout |
protein type: |
Hemoprotein |
Functions: |
oxygen storage/transport |
Domains: |
globin |
Diseases: |
kidney disease, vasospasm |
Taxa expressing: |
many metazoan phyla, Archaea?, protozoan/eubacterial? |
Cell types: |
muscle cells |
Subcellular localization: |
cytoplasm |
covalent modifications |
glycation?, phosphorylation in whales? |
Other names: |
myoglobin-like proteins in microorganisms |
Molecular interactions |
oxygen, carbon monoxide, nitric oxide |
related articles: |
X-ray crystallography, Secondary structure |
Protein info box
Info box example for the protein myoblobin (to right).
Note: only the first (start) and last (finish) template are required. The middle three templates (function, location, other) are options.
{{Protbox start}} template:
- preferred name of the protein
- image for protein (might be structural diagram, cell localization, etc)
- caption for image
- link to gene(s) in database, which gene(s) code for it?
- link to database entry for protein structural info
- links to recent articles at Entrez PubMed.
(To support proteins that do not have an image, this template has been broken down into three components: Template:Protbox header, Template:Protbox image, and Template:Protbox topfields. An alternative to the topfields section is provided in Template:Protbox codes, and a simplified version is at Template:Protein.)
{{Protbox function}} template:
- categorization of the protein; what type of protein is it?
- functions of the protein
- structural domains in the protein
- disease conditions involving the protein
{{Protbox location}} template:
- taxonomic range of expression (wide? restricted?)
- which types of cells express it?
- Subcellular localization.
{{Protbox other}} template:
- covalent modifications with functional significance
- all names that have been applied to the protein
- what other molecules interact with it?
- links to wikipedia pages that discuss the protein
{{Protbox enzyme}} template:
- What reaction it catalyses
- The cofactors involved in the reaction
- Method enzyme is regulated
{{Protbox receptor}} template:
- Receptor actions, e.g. vasoconstriction, neuronal excitation, etc.
- Agonists
- Antagonists
{{Protbox finish}} template:
- This template simply marks the end of a protein information box. (required)
Cell type info box
This will be an information box for displaying basic information about individual cell types.
List of distinct cell types in the adult human body
Some useful references:
- open source cell type ontology project
- http://www.bioeng.auckland.ac.nz/anatml/anatml/database/cells/cells/index.html
- Cell types from Dorland's Medical Dictionary
Basic info could be, name(s), functions, what taxonomic groups has the cell type, etc.
Tissue type(s) that contain the cell type
The major types of proteins that are expressed and that provide the specialized functions of the cell type
I suggest we pick one cell type as an example and get started. I propose skeletal muscle.
Database templates
Templates like this ({{OMIM}}) for the Protein databases, Enzyme Number and PubMed. You'll find these very useful when citing your sources.
Template Name | Usage | Renders As
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Human genetics for a protein/gene:
| {{OMIM|160000}}
| Online 'Mendelian Inheritance in Man' (OMIM) 160000
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Digital object identifier
| {{Doi|10.1038/437794a}}
| doi:10.1038/437794a
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Enzyme number:
| {{EC number|4.1.1.39}}
| EC 4.1.1.39
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Template for Protein Data Bank citations:
| {{Protein Data Bank|9RUB}}
| Protein Data Bank 9RUB
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Template for PubMed Central full text articles
| {{PMC|137841}}
| Full text at PMC: 137841
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Template for Entrez PubMed citations
| {{Entrez Pubmed|10336462}}
| Entrez PubMed 10336462
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Template for Entrez gene citations
| {{EntrezGene|2695}}
| EntrezGene 2695
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Template for RefSeq citations
| {{RefSeq|NM_004123}}
| RefSeq NM_004123
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Template for UniProt citations
| {{UniProt|P09681}}
| UniProt P09681
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Protein topics navigation boxes
See User:Lilious for how to jazz up such navigation boxes.
Templates:
{{Protein topics}}
{{Protein methods}} Protein methods
{{Protein domains}}
{{Cytoskeletal Proteins}}
Proteins of the cytoskeleton |
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Microfilaments | Actins - Actin-binding proteins - Actinin - Arp2/3 complex - Cofilin - Destrin - Gelsolin - Myosins - Profilin - Tropomodulin - Troponin (T, C, I) - Tropomyosin - Wiskott-Aldrich syndrome protein |
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Intermediate filaments | type 1 and 2 (Cytokeratin, type I, type II) - type 3 (Desmin, GFAP, Peripherin, Vimentin) - type 4 (Internexin, Nestin, Neurofilament, Synemin, Syncoilin) - type 5 (Lamin A, B) |
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Microtubules | Dyneins - Kinesins - MAPs (Tau protein, Dynamin) - Tubulins - Stathmin - Tektin |
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Catenins | Alpha catenin - Beta catenin - Plakoglobin (gamma catenin) - Delta catenin |
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Nonhuman | Major sperm proteins - Prokaryotic cytoskeleton (Crescentin, FtsZ, MreB) |
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Other | APC - Dystrophin (Dystroglycan) - plakin (Desmoplakin, Plectin) - Spectrin - Talin - Utrophin - Vinculin |
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Research topic navigation boxes
Example: {{King's College DNA}}
What is a subtemplate?
- {{subst:template}}
- e.g.{{Infobox Molecular and Cellular Biology}}
{{Infobox Molecular and Cellular Biology }}
Stub templates
- {{biochem-stub}} /
- {{molecular-cell-biology-stub}} /
- {{molecular-biology-stub}}
- {{cell-biology-stub}} /
- {{protein-stub}} /
Add to existing categories
{{Molecular and Cellular Biology-category}}
Project banner template
{{Wikiproject MCB}} – A simple to mark articles that are part of this project. It serves, in part, as advertising for the project. It is to placed on the talk page of any articles of interest to this wikiproject.
| This article is within the scope of the Molecular and Cellular Biology WikiProject. To participate, visit the WikiProject for more information. The WikiProject's current monthly collaboration is focused on improving Cellular differentiation.
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Article Grading: The article has not been rated for quality and/or importance yet. Please rate the article and then leave comments here to explain the ratings and/or to identify the strengths and weaknesses of the article.
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Collaboration of the Month templates
Template | What it makes | Where it goes
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{{MCBnom}}
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| This article is a current candidate for the MCB Collaboration of the Month. Please see the project page to find this article's entry to support or comment on the nomination.
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| The talk pages of articles nominated for the MCB Collaboration of the Month.
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{{MCBcur}}
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| Wikipedia:WikiProject Molecular and Cellular Biology/Style guidelines is the current MCB Collaboration of the Month!
CAST YOUR VOTE for next month's article
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| The talk pages of articles that are currently the MCB Collaboration of the Month.
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{{MCBprev | month=MONTH}}
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| This article was the MCB Collaboration of the Month for the month of {{{month}}}. For more details, see the MCB Collaboration of the Month history.
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| The talk pages of articles that were previously an MCB Collaboration of the Month.
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Protein structure templates
{{Protein quaternary structure}} under construction; suggestions welcome!
{{Protein tertiary structure}}
{{Protein structure determination}}
{{Protein secondary structure}}
{{Protein primary structure}}
{{Amino acids}}
Templates for major families of biochemicals
{{Biochemical families}} under construction, overview template, fast cross-link
{{AminoAcids}}
under construction
{{Nucleic acids}}
under construction
Nucleobases:
| Purine (Adenine, Guanine) | Pyrimidine (Uracil, Thymine, Cytosine)
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Nucleosides:
| Adenosine/Deoxyadenosine | Guanosine/Deoxyguanosine | Uridine | Thymidine | Cytidine/Deoxycytidine
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Nucleotides:
| monophosphates (AMP, GMP, UMP, CMP) | diphosphates (ADP, GDP, UDP, CDP) | triphosphates (ATP, GTP, UTP, CTP) | cyclic (cAMP, cGMP, cADPR)
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Deoxynucleotides:
| monophosphates (dAMP, dGMP, TMP, dCMP) | diphosphates (dADP, dGDP, TDP, dCDP) | triphosphates (dATP, dGTP, TTP, dCTP)
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Ribonucleic acids:
| RNA | mRNA (pre-mRNA/hnRNA) | tRNA | rRNA | gRNA | miRNA | ncRNA | piRNA | shRNA | siRNA | snRNA | snoRNA
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Deoxyribonucleic acids:
| DNA | cDNA | gDNA | msDNA | mtDNA
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Nucleic acid analogues:
| GNA | LNA | PNA | TNA | morpholino
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Cloning vectors:
| phagemid | plasmid | lambda phage | cosmid | P1 phage | fosmid | BAC | YAC | HAC
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{{Carbohydrates}} under construction
{{Lipids}}
under construction
{{Terpenoids}} under construction
{{Carotenoids}} under construction
{{Tetrapyrroles}} under construction
{{Enzyme cofactors}}
under construction
{{Steroids}} under construction
{{Flavonoids}} under construction
{{Alkaloids}} under construction
{{Polyketides}} under construction
{{Peptides}} under construction, completing cycle of biochemicals
Other templates
Circulatory system
{{Blood}}
Blood |
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General | Plasma - Hematopoietic stem cells |
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Lymphoid - WBC | T cells: Cytotoxic CD8+, Helper CD4+/Regulatory, γδ, Natural Killer T cell B cells: Plasma, Memory Natural killer cells (Lymphokine-activated killer cell) |
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Myeloid - WBC | Granulocytes (Neutrophil, Eosinophil, Basophil) - Mast cell precursors Dendritic cells (Langerhans cells, Follicular dendritic cells) Monocytes/Macrophages (Histiocytes, Kupffer cells, Langhans giant cells, Microglia, Osteoclasts) Megakaryoblast - Megakaryocyte - Platelets |
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Myeloid - RBC | Reticulocyte - Normoblast |
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Human chromosomes
{{Chromosomes}}
Human chromosomes |
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{1}
{2}
{3}
{4}
{5}
{6}
{7}
{8}
{9}
{10}
{11}
{12}
{13}
{14}
{15}
{16}
{17}
{18}
{19}
{20}
{21}
{22}
{X}
{Y}
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Vitamin-specific template
{{Vitamin}}
Vitamins (A11) |
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fat soluble | A (Retinol, Beta-carotene, Tretinoin, Alpha-carotene) - D (Ergocalciferol, Cholecalciferol, Dihydrotachysterol, Calcitriol, Calcidiol) - E (Tocopherol, Tocotrienol) - K (Naphthoquinone, Phylloquinone/K1, Menatetrenone/K2) |
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water soluble: B vitamins | B1 (Thiamine, Sulbutiamine, Benfotiamine) - B2 (Riboflavin) - B3 (Niacin, Nicotinamide) - B5 (Pantothenic acid, Dexpanthenol, Pantethine) - B6 (Pyridoxine, Pyridoxal phosphate) - B7 (Biotin) - B9 (Folic acid) - B12 (Cyanocobalamin, Hydroxocobalamin, Methylcobalamin, Cobamamide) |
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water soluble: other | C (Ascorbic acid) - Choline |
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Endocrinology template (hormones and glands)
{{hormones}}
Endocrine system: hormones/endocrine glands (Peptide hormones, Steroid hormones) |
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Hypothalamic-pituitary | Hypothalamus: TRH, CRH , GnRH, GHRH, somatostatin, dopamine - Posterior pituitary: vasopressin, oxytocin - Anterior pituitary: α (FSH, LH, TSH), GH, prolactin, POMC (ACTH, MSH, endorphins, lipotropin) |
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Adrenal axis | Adrenal medulla: epinephrine, norepinephrine - Adrenal cortex: aldosterone, cortisol, DHEA |
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Thyroid axis | Thyroid: thyroid hormone (T3 and T4) - calcitonin - Parathyroid: PTH |
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Gonadal axis | Testis: testosterone, AMH, inhibin - Ovary: estradiol, progesterone, inhibin/activin, relaxin (pregnancy) |
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Other end. glands | Pancreas: glucagon, insulin, somatostatin - Pineal gland: melatonin |
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Non-end. glands | Placenta: hCG, HPL, estrogen, progesterone - Kidney: renin, EPO, calcitriol, prostaglandin - Heart atrium: ANP - Stomach: gastrin, ghrelin - Duodenum: CCK, GIP, secretin, motilin, VIP - Ileum: enteroglucagon - Adipose tissue: leptin, adiponectin, resistin - Thymus: Thymosin - Thymopoietin - Skeleton: Osteocalcin - Liver/other: Insulin-like growth factor (IGF-1, IGF-2) |
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Target-derived | NGF, BDNF, NT-3 |
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