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Protriptyline


Protriptyline
Systematic (IUPAC) name
N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine
Identifiers
CAS number	438-60-8
ATC code	N06AA11
PubChem	4976
Chemical data
Formula	C₁₉H₂₁N
Mol. mass	263.377 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	Hepatic
Half life	54-92 hours
Excretion	Renal, in urine
Therapeutic considerations
Pregnancy cat.	C(US)
Legal status	Schedule VI (US)
Routes	Oral

Protriptyline (Vivactil®) is a tricyclic antidepressant (TCA), specifically a secondary amine, indicated for depression and ADHD. Unique among the tricyclics, protriptyline tends to be energizing instead of sedating, and it is sometimes used in narcolepsy to achieve a wakefulness-promoting effect.^{[citation needed]} (The other TCAs tend to be sedating and therefore are often taken in the evening.)

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Tricyclics including protriptyline are also used to reduce the incidence of recurring headaches such as migraine, and for other types of chronic pain.

v • d • e

Psychoanaleptics: antidepressants (N06A)

MAOIs

Iproclozide • Iproniazid • Isocarboxazid • Nialamide • Pargyline • Phenelzine • Rasagiline • Selegiline • Toloxatone • Tranylcypromine
RIMAs: Brofaromine • Beta-carbolines (Harmaline) • Moclobemide

RIs

S RI	SS RI (Alaproclate, Citalopram, Dapoxetine, Escitalopram, Etoperidone, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Zimelidine) • TCAs/Tetras (Clomipramine, Nefazodone, Trazodone)
N RI / A RI	Atomoxetine • Maprotiline • Reboxetine • Viloxazine • TCAs/Tetras (Amitriptyline, Amoxapine, Butriptyline, Desipramine/Lofepramine, Dibenzepin, Dothiepin, Doxepin, Imipramine, Iprindole, Melitracen, Nortriptyline, Opipramol, Protriptyline, Trimipramine, Maprotiline)
D RI	Vanoxerine • Phenmetrazine • TCAs (Amineptine)
SN RI	Bicifadine • Desvenlafaxine • Duloxetine • Milnacipran • Nefazodone • Venlafaxine
ND RI	Bupropion
SND RI	Brasofensine • Tesofensine • Nomifensine