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Valofane


Valofane
Systematic (IUPAC) name
N-carbamoyl-5-methyl-2-oxo-3-prop-2-enyloxolane-3-carboxamide
Identifiers
CAS number	3258-51-3
ATC code	?
PubChem	71122
Chemical data
Formula	C₁₀H₁₄N₂O₄
Mol. mass	226.229 g/mol
Synonyms	Valofan, Valofane
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Valofane is a sedative drug structurally related to the barbiturates^[1] and similar drugs such as primidone. It is metabolised once inside the body to form the barbiturate proxibarbal and is thus a prodrug.^[2]

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References

^ Traversa U, Puppini P, Jacquot C, Vertua R. Effect of an atypical barbiturate, the 2-allophanyl-2-allyl-4-valerolactone (valofan), on exploratory behaviour and brain serotonin concentrations in mice. Journal de Pharmacologie. 1985 Jul-Sep;16(3):279-90.
^ Lambrey B, Compagnon PL, Jacquot C. Pharmacokinetics of 14C-2-allophanyl-2-allyl -gamma-valero-lactone: a prodrug of proxibarbal in rats. European Journal of Drug Metabolism and Pharmacokinetics. 1981;6(3):161-9.