Uremia Classification & external resources
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Urea
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ICD-10
| R39.2
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ICD-9
| 585-586, 788.9
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DiseasesDB
| 26060
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eMedicine
| med/2341
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MeSH
| D014511
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Uremia is a term used to loosely describe the illness accompanying kidney failure (also called renal failure). In kidney failure, urea and other waste products, which are normally excreted into the urine, are retained in the blood. Early symptoms include anorexia and lethargy, and late symptoms can include decreased mental acuity and coma. It is usually diagnosed in kidney dialysis patients when the glomerular filtration rate, a measure of kidney function, is below 50% of normal.[1]
Additional recommended knowledge
Azotemia is another word that refers to high levels of urea, but is used primarily when the abnormality can be measured chemically but is not yet so severe as to produce symptoms. Uremia can also result in fibrinous pericarditis. There are many dysfunctions caused by uremia affecting many systems of the body, such as blood (lower levels of erythropoietin), Sex (lower levels of testosterone/oestrogen) and bones (osteoperosis
and metastatic calcifications).
Causes
Besides renal failure, the level of urea in the blood can also be increased by:
- increased production of urea in the liver, due to:
- high protein diet
- increased protein breakdown (surgery, infection, trauma, cancer)
- gastrointestinal bleeding
- drugs (e.g. tetracyclines and corticosteroids)
- decreased elimination of urea, due to:
- decreased blood flow through kidney (e.g. hypotension, cardiac failure)
- urinary outflow obstruction
References
- ^ Meyer TW and Hostetter, TH (2007). "Uremia". N Engl J Med 357 (13): 1316. PMID 17898101. Full text.
See also
- Azotemia
- Nephrology
- Renal failure
Symptoms and signs (R00-R69, 780-789) |
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Circulatory and respiratory systems | Tachycardia - Bradycardia - Palpitation - Heart murmur - Epistaxis - Hemoptysis - Cough - abnormalities of breathing (Dyspnea, Orthopnoea, Stridor, Wheeze, Cheyne-Stokes respiration, Hyperventilation, Mouth breathing, Hiccup, Bradypnea, Hypoventilation) - Chest pain - Asphyxia - Pleurisy - Respiratory arrest - Sputum - Bruit/Carotid bruit - Rales |
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Digestive system and abdomen | Abdominal pain (Acute abdomen) - Nausea/Vomiting - Heartburn - Dysphagia - flatulence and related (Abdominal distension, Bloating, Burping, Tympanites) - Fecal incontinence (Encopresis) - hepatosplenomegaly (Hepatomegaly, Splenomegaly) - Jaundice - Ascites - Fecal occult blood - Halitosis |
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Skin and subcutaneous tissue | disturbances of skin sensation (Hypoesthesia, Paresthesia, Hyperesthesia) - Rash - Cyanosis - Pallor - Flushing - Petechia - Desquamation - Induration - Diaphoresis |
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Nervous and musculoskeletal systems | abnormal involuntary movements (Tremor, Spasm, Fasciculation, Athetosis) - Gait abnormality - lack of coordination (Ataxia, Dysmetria, Dysdiadochokinesia, Hypotonia) - Tetany - Meningism - Hyperreflexia |
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Urinary system | Renal colic - Dysuria - Vesical tenesmus - Urinary incontinence - Urinary retention - Oliguria - Polyuria - Nocturia - Extravasation of urine - Extrarenal uremia |
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Cognition, perception, emotional state and behaviour | Anxiety - Somnolence - Coma - Amnesia (Anterograde amnesia, Retrograde amnesia) - Dizziness/Vertigo - smell and taste (Anosmia, Ageusia, Parosmia, Parageusia) |
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Speech and voice | speech disturbances (Dysphasia, Aphasia, Dysarthria) - symbolic dysfunctions (Dyslexia, Alexia, Agnosia, Apraxia, Acalculia, Agraphia) - voice disturbances (Dysphonia, Aphonia) |
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General symptoms and signs | Fever (Hyperpyrexia) - Headache - Chronic pain - Malaise/Fatigue (Asthenia, Debility) - Fainting (Vasovagal syncope) - Febrile seizure - Shock (Cardiogenic shock) - Lymphadenopathy - Edema (Peripheral edema, Anasarca) - Hyperhidrosis (Sleep hyperhidrosis) - Delayed milestone - Failure to thrive - Short stature (Idiopathic) - food and fluid intake (Anorexia, Polydipsia, Polyphagia) - Cachexia - Xerostomia - Clubbing |
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