Type I cytokine receptor

Type I cytokine receptors are proteins expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands. These receptors are also known under the name hemopoietin receptors, and share a common amino acid motif (WSXWS) in the extracellular portion adjacent to the cell membrane. Members of the type I cytokine receptor family comprise different chains, some of which are involved in ligand/cytokine interaction and others that are involved in signal transduction.

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Families

The signal transducing chains are often shared between different receptors within this receptor family.^[1]

• The IL-2 receptor common gamma chain (also known as CD132) is shared between IL-2, IL-4, IL-7, IL-9, IL-13 and IL-15 receptors^[2]

• The common beta chain (CD131 or CDw131) is shared between GM-CSF, IL-3 and IL-5.^[3]

Examples

Type I cytokine receptors include:

• Interleukin-2 receptor
• Interleukin-3 receptor
• Interleukin-4 receptor
• Interleukin-5 receptor
• Interleukin-6 receptor
• Interleukin-7 receptor
• Interleukin-9 receptor
• Interleukin-11 receptor
• Interleukin-12 receptor
• Interleukin-13 receptor
• Interleukin-15 receptor
• Erythropoietin receptor
• GM-CSF receptor
• G-CSF receptor
• growth hormone receptor
• prolactin receptor

References

1. ^ Abbas AK, and Lichtman, Cellular and Molecular Immunology (5th Ed.) Editor: Saunders, Philadelphia, 2003.
2. ^ He et al., Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor. J Immunol. 1995 Feb 15;154(4):1596-605
3. ^ Woodcock et al., Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF. EMBO J. 1994 November 1; 13(21): 5176–5185.