Type II cytokine receptor

Type II cytokine receptors are transmembrane proteins that are expressed on the surface of certain cells, which bind and respond to a select group of cytokines. These receptors are similar to type I cytokine receptors except they do not possess the signature sequence WSXWS that is characteristic of type I receptors.

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Structure

Typically type II cytokine receptors will comprise two polypeptide chains, one for signaling and the other for ligand binding. These receptors are related predominantly by similarities in their extracellular portions that are composed of tandem fibronectin type III domains. The intracellular domain of type II cytokine receptors is typically associated with a tyrosine kinase belonging to the Janus kinase (JAK) family.

Ligands

The ligands that bind the type II cytokine receptors include type I and type II interferons, and members of the interleukin-10 family (interleukin-10, interleukin-20 and interleukin-22).^[1][2]

References

1. ^ Dumoutier L, Lejeune D, Hor S, Fickenscher H, Renauld JC (2003). "Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3". Biochem. J. 370 (Pt 2): 391-6. doi:10.1042/BJ20021935. PMID 12521379.
2. ^ Xu W, Presnell SR, Parrish-Novak J, et al (2001). "A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9511-6. doi:10.1073/pnas.171303198. PMID 11481447.