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Triprolidine



Triprolidine
Systematic (IUPAC) name
2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-yl-
prop-1-enyl]pyridine
Identifiers
CAS number 486-12-4
ATC code R06AX07
PubChem 5282443
DrugBank APRD00306
Chemical data
Formula C19H22N2 
Mol. mass 278.391 g/mol
SMILES search in eMolecules, PubChem
Physical data
Melt. point 60 °C (140 °F)
Solubility in water 500 mg/mL (20 °C)
Pharmacokinetic data
Bioavailability 4% oral
Protein binding 90%
Metabolism Hepatic (CYP2D6)
Half life 4 to 6 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

C (US)

Legal status

OTC (US)

Routes Oral

Triprolidine hydrochloride is an over-the-counter antihistamine. It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms. Like many over-the-counter antihistamines, the most common side effect is drowsiness.

Trade names

Note: in some countries (Belgium e.g.), ACTIFED contains pseudoephedrine and triprolidine, but the same pharmaceutical company (GSK) has introduced an "ACTIFED New" which contains dextromethorphan hydrobromide, an anti-tussive compound unrelated to pseudoephedrine and triprolidine, and with different indications (symptomatic treatment of non-productive, irritative cough).

v • d • e
Antihistamines (primarily R06)
Aminoalkyl ethersBromazine • Carbinoxamine • Clemastine • Chlorphenoxamine • Diphenylpyraline • Diphenhydramine • Doxylamine • Orphenadrine • Phenyltoloxamine
Substituted alkylaminesBrompheniramine • Chlorphenamine • Dexbrompheniramine • Dexchlorpheniramine • Dimetindene • Pheniramine • Talastine
Substituted ethylenediaminesChloropyramine • Histapyrrodine • Mepyramine • Methapyrilene • Tripelennamine (Pyribenzamine)
Phenothiazine derivativesAlimemazine • Hydroxyethylpromethazine • Isothipendyl • Mequitazine • Methdilazine • Oxomemazine • Promethazine
Piperazine derivativesBuclizine • Cetirizine • Chlorcyclizine • Cinnarizine • Cyclizine • Hydroxyzine • Levocetirizine • Meclizine • Niaprazine • Oxatomide
Others for systemic useAntazoline • Azatadine • Bamipine • Cyproheptadine • Deptropine • Dimebon • Ebastine • Epinastine • Ketotifen • Mebhydrolin • Mizolastine • Phenindamine • Pimethixene • Pyrrobutamine • Rupatadine • Triprolidine • selective (Acrivastine • Astemizole • Azelastine • Desloratadine • Fexofenadine • Loratadine • Terfenadine)
For topical useBamipine • Chloropyramine • Chlorphenoxamine • Clemastine • Dimetindene • Diphenhydramine • Isothipendyl • Mepyramine • Promethazine • Thenalidine
Antiallergic agents excluding corticosteroidsAntazoline • Azelastine
Other antiallergicsEmedastine • Epinastine • Ketotifen • Olopatadine
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Triprolidine". A list of authors is available in Wikipedia.
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