Trimethylsilanol

Trimethylsilanol (TMS), also trimethylhydroxysilane, is an organosilicon chemical compound with the formula (CH₃)₃SiOH, or C₃H₁₀OSi. It is an organic derivate of silane substituted with three methyls and one hydroxyl group. It is a volatile organic liquid with boiling point between 98.6-99 °C. [1066-40-6]

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TMS is used to apply hydrophobic coating on silicate surfaces. It reacts with the silicone atoms of the substrate, coating the surface with a layer of methyl groups. A commercial example is Magic Sand.

TMS is a common contaminant in spacecraft atmospheres, where it is present due to outgassing of silicone-based materials. [1] It is a potential end group hydrolysis product of polydimethylsiloxane chains.

TMS, together with other silanols, is also being investigated as an antimicrobial agent. [2]