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Trilostane


Trilostane
Systematic (IUPAC) name
?
Identifiers
CAS number	13647-35-3
ATC code	H02CA01
PubChem	656583
DrugBank	APRD01276
Chemical data
Formula	C₂₀H₂₇N O₃
Mol. mass	329.433 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	8 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	Withdrawn (U.S.)
Routes	?

Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome.^[1] It was withdrawn from the United States market in April 1994.

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References

^ Komanicky P, Spark RF, Melby JC. (1978). "Treatment of Cushing's syndrome with trilostane (WIN 24,540), an inhibitor of adrenal steroid biosynthesis". Journal of Clinical Endocrinology and Metabolism 47 (5): 1042–1051. PMID 233687. Retrieved on 2007-06-17.

v • d • e Corticosteroids for systemic use (H02)
Mineralocorticoids	Aldosterone - Fludrocortisone - Desoxycortone
Glucocorticoids	Betamethasone - Dexamethasone - Fluocortolone - Methylprednisolone - Paramethasone - Prednisolone - Prednisone - Triamcinolone - Hydrocortisone - Cortisone - Prednylidene - Rimexolone - Deflazacort - Cloprednol - Meprednisone - Cortivazol
Anticorticosteroids	Trilostane