Trans-splicing

Trans-splicing is a special form of RNA processing in eukaryotes where exons from two different primary RNA transcripts are joined end to end and ligated.

Additional recommended knowledge

Essential Laboratory Skills Guide

What is the Correct Way to Check Repeatability in Balances?

Daily Sensitivity Test

In contrast "normal" (cis-)splicing processes a single molecule. That is, trans-splicing results in a RNA transcript that came from multiple RNA polymerases on the genome.

References

• Dixon RJ, Eperon IC, Samani NJ (2007). "Complementary intron sequence motifs associated with human exon repetition: a role for intragenic, inter-transcript interactions in gene expression". Bioinformatics 23 (2): 150-5. doi:10.1093/bioinformatics/btl575. PMID 17105720.
• Yang Y, Walsh CE (2005). "Spliceosome-mediated RNA trans-splicing". Mol. Ther. 12 (6): 1006-12. doi:10.1016/j.ymthe.2005.09.006. PMID 16226059.