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Trans-2-Phenyl-1-cyclohexanolTemplate:DISPLAYTITLE:trans-2-Phenyl-1-cyclohexanol trans-2-Phenyl-1-cyclohexanol is an organic compound. The two enantiomers of this compound are used in organic chemistry as chiral auxiliaries. Additional recommended knowledgePreparationThe enantioselective synthesis was accomplished by J. K. Whitesell by adding Pseudomonas fluorescens lipase to racemic trans-2-phenylcyclohexyl chloroacetate.[1][2] This enzyme is able to hydrolize the ester bond of the (-) enantiomer but not the (+) enantiomer. The (-)-cyclohexanol and the (+)-ester are separated by fractional crystallization and the isolated (+)-ester hydrolyzed to the (-)-cyclohexanol in a separate step. The enantiomers have also been prepared by the Sharpless asymmetric dihydroxylation of 1-phenylcyclohexene to the diol followed by the selective reduction of the 1-hydroxyl group by Raney nickel.[3]
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Trans-2-Phenyl-1-cyclohexanol". A list of authors is available in Wikipedia. |