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Topicort


Topicort
Systematic (IUPAC) name
(8S,9S,10S,11S,13S,14S,16R,17S)-9-fluoro-11- hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl- 7,8,11,12,14,15,16,17-octahydro-6H- cyclopenta[a]phenanthren-3-one
Identifiers
CAS number	382-67-2
ATC code	D07AC03 D07XC02
PubChem	5311067
DrugBank	APRD00910
Chemical data
Formula	C₂₂H₂₉F O₄
Mol. mass	376.462 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Topicort is a medication belonging to the family of medications known as topical corticosteroids. It is used for the relief of various skin conditions, including rashes. It helps to reduce redness, itching, and irritation. There are two brand name products:

Topicort® Emollient Cream(desoximetasone) 0.25%
Topicort® LP Emollient Cream (desoximetasone) 0.05%

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Topicort® (desoximetasone) Emollient Cream 0.25% and Topicort® LP (desoximetasone) Emollient Cream 0.05% both contain the active synthetic corticosteroid desoximetasone. The topical corticosteroids constitute a class of primarily synthetic steroids used as anti-inflammatory and anti-pruritic agents.

Each gram of TOPICORT Emollient Cream 0.25% contains 2.5 mg of Desoximetasone in an emollient cream consisting of White Petrolatum USP, Purified Water USP, Isopropyl Myristate NF, Lanolin Alcohols NF, Mineral Oil USP, Cetostearyl Alcohol NF, Aluminum Stearate, and Magnesium Stearate.

Each Gram of TOPICORT LP Emollient Cream 0.05% contains 0.5 mg Desoximetasone in an emollient cream consisting of White Petrolatum USP, Purified Water USP, Isopropyl Myristate NF, Lanolin Alcohols NF, Mineral Oil USP, Cetostearyl Alcohol NF, Aluminum Stearate, Edetate Disodium USP, Lactic Acid USP and Magnesium Stearate.

The chemical name of desoximetasone is Pregna-1, 4-diene-3, 20-dione, 9-fluoro-11, 21-dihydroxy-16-methyl-, (11β, 16α)-. Desoximetasone has the empirical formula C22H29FO4 and a molecular weight of 376.47. The CAS Registry Number is 382-67-2.

Uses

When use Topicort, you may absorb some of the medication through your skin and into the bloodstream. Too much absorption can lead to unwanted side effects elsewhere in the body. To keep this problem to a minimum, avoid using large amounts of Topicort over large areas, do not use it for extended periods of time, and do not cover it with airtight dressings such as plastic wrap or adhesive bandages unless specifically told to by your doctor.

Children may absorb more medication than adults do. Topicort is for use only on the skin. Be careful to keep it out of your eyes. Apply a thin coating of Topicort to the affected area. Rub in gently. The treated area should not be covered unless your doctor has told you to do so.

If Topicort is being used for an infant or toddler with a genital rash, make sure the diapers or plastic pants are not too tight, so that air can circulate. Use Topicort only as needed, in the smallest amount required for relief. Store Topicort at room temperature.