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Tiratricol


Tiratricol
Systematic (IUPAC) name
2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl] acetic acid
Identifiers
CAS number	51-24-1
ATC code	H03AA04 D11AX08
PubChem	5803
Chemical data
Formula	C₁₄H₉I₃O₄
Mol. mass	621.932 g/mol
Synonyms	3,3',5-triiodothyroacetic acid TRIAC
Pharmacokinetic data
Bioavailability	?
Protein binding	Presumed high
Metabolism	Hepatic glucuronidation
Half life	?
Excretion	Biliary
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Tiratricol (also known as TRIAC) is a thyroid hormone analogue. It is indicated in the management of thyroid hormone resistance syndrome^[1] and is used, in combination with levothyroxine, to suppress thyroid-stimulating hormone production in patients with thyroid cancer.

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Tiratricol has also been widely marketed, under various trade names, as a weight loss aid. In 1999 and 2000, the United States Food and Drug Administration and Health Canada both issued warnings to the public regarding the use of dietary supplements containing tiratricol.^[2]^[3]

Legal status

Tiratricol is not approved for sale in Canada or the United States. It was once an approved drug in Brazil, but its marketing authorization was suspended in 2003, effectively prohibiting its sale.^[4]

References

^ Carvalho GA, Ramos HE (2004). "[Thyroid hormone resistance syndrome]" (in Portuguese). Arq Bras Endocrinol Metabol 48 (1): 83–92. doi:/S0004-27302004000100010. PMID 15611821. Free full textPDF (95.3 KiB)
^ U.S. Food and Drug Administration (November 21 2000). "FDA Warns Against Consuming Dietary Supplements Containing Tiratricol". Press release. Retrieved on 2007-08-08.
^ Health Canada (December 2 1999). "Health Canada issues warning on products containing Tiratricol (TRIAC)". Press release. Retrieved on 2007-08-08.
^ Anvisa suspende Tiratricol (Portuguese). Brazilian Society of Endocrinology and Metabolism. Retrieved on 2007-08-08.

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Other dermatologicals	seborrhoeic dermatitis/dandruff (Lithium succinate, Pyrithione zinc) - skin whitening/depigmenting (Hydroquinone, Mequinol, Monobenzone) - anti-inflammatory/Immunomodulators (Oxaceprol, Gamolenic acid), Pimecrolimus, Tacrolimus) - baldness treatments (Finasteride, Minoxidil) - hair growth inhibiting agent (Eflornithine) - other (Calcium gluconate, Magnesium sulfate, Tiratricol)

v • d • e Thyroid therapy (H03)
Thyroid hormones	Levothyroxine sodium - Liothyronine sodium - Tiratricol - Thyroid gland preparations
Antithyroid preparations	Thiouracils (Methylthiouracil, Propylthiouracil, Benzylthiouracil) - Sulphur-containing imidazole derivatives (Carbimazole, Thiamazole) - Perchlorates (Potassium perchlorate) - Other (Diiodotyrosine, Dibromotyrosine)

Category: Orphan drugs

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Tiratricol". A list of authors is available in Wikipedia.