Thorpe reaction

The Thorpe reaction is a chemical reaction described as a self-condensation of aliphatic nitriles catalyzed by base to form enamines.^[1][2][3]

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Thorpe-Ziegler reaction

The Thorpe-Ziegler reaction or Ziegler method is the intramolecular modification with a dinitrile as a reactant and a cyclic ketone as the final reaction product after acidic hydrolysis. The reaction is conceptually related to the Dieckmann condensation.

References

1. ^  Baron, H.; Remfry, F. G. P.; Thorpe, Y. F. J. Chem. Soc. 1904, 85, 1726.
2. ^  Ziegler, K. et al. Ann. 1933, 504, 94.
3. ^  Schaefer, J. P.; Bloomfield, J. J. Org. React. 1967, 15, 1. (Review)