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Tiopronin


Tiopronin
Systematic (IUPAC) name
[(2-mercaptopropanoyl)amino]acetic acid
Identifiers
CAS number	1953-2-2
ATC code	R05CB12
PubChem	5483
Chemical data
Formula	C₅H₉N O₃S
Mol. mass	163.196 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	C(US)
Legal status	℞-only(US)
Routes	?

Tiopronin (trade name Thiola) is a prescription thiol drug used to control the rate of cystine solidification and excretion in the disease cystinuria. It is a white crystalline powder. Due to its rarity, it falls under the classification of "orphan drug".

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Side effects

Tiopronin may present a wide variety of side effects, but side effects are usually limited and subside over time with continued usage. With the rarity of the disease, tiopronin has not been studied substantially, with an extremely low percentage of individuals available for testing.

Other uses

Tiopronin is used primarily for cystinuria and is well known in the cystinuric community. It may also be used for Wilson's disease (an overload of copper in the body), and certain types of rare arthritis. It should be mentioned though, that tiopronin is not an anti-inflammatory.

Depending on the severity of a person's cystinuria, tiopronin may be taken for life, possibly starting in early childhood.

References

Thiola Main Site

v • d • e Cough and cold preparations (R05)
Expectorants	Tyloxapol - Potassium iodide - Guaifenesin - Ipecacuanha - Althea root - Senega - Antimony pentasulfide - Creosote - Guaiacolsulfonate - Levoverbenone
Mucolytics	Acetylcysteine - Bromhexine - Carbocisteine - Eprazinone - Mesna - Ambroxol - Sobrerol - Domiodol - Letosteine - Stepronin - Tiopronin - Dornase alfa - Neltenexine - Erdosteine
Cough suppressants: Opium alkaloids and derivatives	Ethylmorphine - Hydrocodone - Codeine - Normethadone - Noscapine - Pholcodine - Dextromethorphan - Thebacon - Dimemorfan - Acetyldihydrocodeine - Zipeprol
Other cough suppressants	Benzonatate - Benproperine - Clobutinol - Isoaminile - Pentoxyverine - Oxolamine - Oxeladin - Clofedanol - Pipazetate - Bibenzonium bromide - Butamirate - Fedrilate - Dibunate - Droxypropine - Prenoxdiazine - Dropropizine - Cloperastine - Meprotixol - Piperidione - Tipepidine - Morclofone - Nepinalone - Levodropropizine - Dimethoxanate