TheraSphere

TheraSphere is a hepatocellular carcinoma (HCC) treatment therapy that consists of millions of microscopic, radioactive glass microspheres (20-30 micrometres in diameter) being infused into the arteries that feed liver tumors, bathing the malignancy in high levels of ⁹⁰Y radiation. It is currently approved for patients as a neoadjuvant to surgery or transplantation by the US FDA and is being used at a number of clinical centers in the United States.

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Description

TheraSphere consists of insoluble glass microspheres where Yttrium-90 is an integral constituent of the glass. Each milligram contains between 22,000 and 73,000 microspheres. Yttrium-90 is a pure beta emitter and decays to stable zirconium-90 with a physical half-life of 64.2 hours (2.67 days). The average energy of the beta emissions from yttrium-90 is 0.9367 MeV.

Following embolization of the yttrium-90 glass microspheres in tumorous liver tissue, the beta radiation emitted provides a therapeutic effect. The microspheres are delivered into the liver tumor through a catheter placed into the hepatic artery that supplies blood to the tumor(This is usually performed in a hospital's radiology suite and patients remain conscious throughout the procedure). The microspheres are unable to pass through the vasculature of the liver due to arteriolar capillary blockade and are trapped in the tumor. There they exert a local radiotherapeutic effect with some damage to surrounding normal liver tissue.^[1][2]

Efficacy

Low-risk patients with unresectable liver cancer appear to gain control over their malignancies for at least 2 years when treated with TheraSphere. They survived a median of 800 days compared with a median of 258 days for high risk patients (P <.0001) in a study of 140 patients (106 male). The patients underwent 238 administrations of the particles. Approximately 34% of patients responded to the treatment according to evaluation by Response Evaluation Criteria in Solid Tumors (RECIST), meaning their overall tumor burden decreased by 50% or more.^[3]

In a separate study based on follow-up data from 43 treated patients, 20 patients (47%) had an objective tumor response based on percent reduction in tumor size and 34 patients (79%) had a tumor response when percent reduction and/or tumor necrosis were used as a composite measure of tumor response.^[4]

References