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Tertiary hydrogen bond

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1 Introduction
2 Definition
3 See also
4 References

Introduction

Hydrogen bonding interaction in proteins plays a crucial role in protein folding, dynamics and function. A few percent of hydrogen bonds connect distant amino acid residues and are not involved in secondary structure stabilization. These hydrogen bonds have special role in the proteins and called tertiary hydrogen bonds ^[1]. Tertiary hydrogen bonds can be viewed as a network enabling fast and specific (directional) communication over the whole protein.

Definition

Hydrogen bonds that stabilize the tertiary structure of the proteins
Off-diagonal points in the HB plot

References

^ Bikadi Z, Demko L, Hazai E (2007). "Functional and structural characterization of a protein based on analysis of its hydrogen bonding network by hydrogen bonding plot". Arch Biochem Biophys. 461 (2): 225-234. doi:10.1016/j.abb.2007.02.020.

Category: Protein structure