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Terlipressin
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Systematic (IUPAC) name
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(2S)-1-[(4S,7S,10S,13S,16S,19S)-19-[[2- [[2-[(2-Aminoacetyl)amino]acetyl]amino] acetyl]amino]-13-benzyl-10-(2-carbamoylethyl)- 7-(carbamoylmethyl)-16-[(4-hydroxyphenyl) methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8, 11,14,17-pentazacycloicosane-4-carbonyl]-N- [(1S)-5-amino-1-(carbamoylmethylcarbamoyl) pentyl]pyrrolidine-2-carboxamide
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Identifiers
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CAS number
| 14636-12-5
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ATC code
| H01BA04
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PubChem
| 72081
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DrugBank
| EXPT03310
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Chemical data
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Formula | C52H74N16O15S2
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Mol. mass | 1227.37 g/mol
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Pharmacokinetic data
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Bioavailability | ?
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Protein binding
| ~30%
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Metabolism | ?
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Half life | ?
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Excretion | ?
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Therapeutic considerations
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Pregnancy cat.
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?
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Legal status
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Routes
| IV
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Terlipressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help.
Additional recommended knowledge
Indications for use include norepinephrine-resistant septic shock[1] and hepatorenal syndrome.[2] In addition, it is used in bleeding esophageal varices.[3]
Terlipressin is marketed under the brand name Glypressin (Ferring Pharmaceuticals).
See also
References
- ^ O'Brien A, Clapp L, Singer M (2002). "Terlipressin for norepinephrine-resistant septic shock". Lancet 359 (9313): 1209–10. PMID 11955542.
- ^ Uriz J, Ginès P, Cárdenas A, Sort P, Jiménez W, Salmerón J, Bataller R, Mas A, Navasa M, Arroyo V, Rodés J (2000). "Terlipressin plus albumin infusion: an effective and safe therapy of hepatorenal syndrome". J Hepatol 33 (1): 43–8. PMID 10905585.
- ^ Ioannou G, Doust J, Rockey D. "Terlipressin for acute esophageal variceal hemorrhage". Cochrane Database Syst Rev: CD002147. PMID 12535432.
Pituitary and hypothalamic hormones and analogues (H01) |
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Anterior pituitary | Adrenocorticotropic hormone (Corticotropin, Tetracosactide) - Thyrotropin - Somatropin/agonists (Somatrem, Mecasermin, Sermorelin) - other (Pegvisomant) |
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Posterior pituitary | Vasopressin (Desmopressin, Lypressin, Terlipressin, Ornipressin, Argipressin) - Oxytocin (Demoxytocin, Carbetocin) |
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Hypothalamic | gonadotropin-releasing hormones (Gonadorelin, Nafarelin, Histrelin) - antigrowth hormone (Somatostatin, Octreotide, Lanreotide) - anti-gonadotropin-releasing hormones (Ganirelix, Cetrorelix) |
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