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Terlipressin


Terlipressin
Systematic (IUPAC) name
(2S)-1-[(4S,7S,10S,13S,16S,19S)-19-[[2- [[2-[(2-Aminoacetyl)amino]acetyl]amino] acetyl]amino]-13-benzyl-10-(2-carbamoylethyl)- 7-(carbamoylmethyl)-16-[(4-hydroxyphenyl) methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8, 11,14,17-pentazacycloicosane-4-carbonyl]-N- [(1S)-5-amino-1-(carbamoylmethylcarbamoyl) pentyl]pyrrolidine-2-carboxamide
Identifiers
CAS number	14636-12-5
ATC code	H01BA04
PubChem	72081
DrugBank	EXPT03310
Chemical data
Formula	C₅₂H₇₄N₁₆O₁₅S₂
Mol. mass	1227.37 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	~30%
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	IV

Terlipressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help.

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Indications for use include norepinephrine-resistant septic shock^[1] and hepatorenal syndrome.^[2] In addition, it is used in bleeding esophageal varices.^[3]

Terlipressin is marketed under the brand name Glypressin (Ferring Pharmaceuticals).

References

^ O'Brien A, Clapp L, Singer M (2002). "Terlipressin for norepinephrine-resistant septic shock". Lancet 359 (9313): 1209–10. PMID 11955542.
^ Uriz J, Ginès P, Cárdenas A, Sort P, Jiménez W, Salmerón J, Bataller R, Mas A, Navasa M, Arroyo V, Rodés J (2000). "Terlipressin plus albumin infusion: an effective and safe therapy of hepatorenal syndrome". J Hepatol 33 (1): 43–8. PMID 10905585.
^ Ioannou G, Doust J, Rockey D. "Terlipressin for acute esophageal variceal hemorrhage". Cochrane Database Syst Rev: CD002147. PMID 12535432.

v • d • e Pituitary and hypothalamic hormones and analogues (H01)
Anterior pituitary	Adrenocorticotropic hormone (Corticotropin, Tetracosactide) - Thyrotropin - Somatropin/agonists (Somatrem, Mecasermin, Sermorelin) - other (Pegvisomant)
Posterior pituitary	Vasopressin (Desmopressin, Lypressin, Terlipressin, Ornipressin, Argipressin) - Oxytocin (Demoxytocin, Carbetocin)
Hypothalamic	gonadotropin-releasing hormones (Gonadorelin, Nafarelin, Histrelin) - antigrowth hormone (Somatostatin, Octreotide, Lanreotide) - anti-gonadotropin-releasing hormones (Ganirelix, Cetrorelix)