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Sulfadiazine



Sulfadiazine
Systematic (IUPAC) name
4-amino-N-pyrimidin-2-yl-benzenesulfonamide
Identifiers
CAS number	68-35-9
ATC code	J01EC02
PubChem	2215
DrugBank	APRD00190
Chemical data
Formula	C₁₀H₁₀N₄O₂S
Mol. mass	250.278 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	Approved Drug
Routes	Cream

Sulfadiazine is a sulfonamide antibiotic. It eliminates bacteria that cause infections by stopping the production of folic acid inside the bacterial cell, and is commonly used to treat urinary tract infections (UTIs).

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In combination, sulfadiazine and pyrimethamine, can be used to treat toxoplasmosis, a disease caused by Toxoplasma gondii. This may present in an AIDS patient as multiple ring enhancing lesions on CT. Pregnant women should avoid contact with cat litter which may contain Toxoplasma oocysts.

Side effects reported for sulfadiazine include: nausea, upset stomach, loss of appetite, and dizziness.

Brand Names

Lantrisul; Neotrizine; Sulfa-Triple #2; Sulfadiazine; Sulfaloid; Sulfonamides Duplex; Sulfose; Terfonyl; Triple Sulfa; Triple Sulfas; Triple Sulfoid

v • d • e Antibacterials for systemic use: sulfonamides (sulfa drugs) and trimethoprim (J01E)
Trimethoprim and derivatives	Trimethoprim • Brodimoprim
Short-acting sulfonamides	Sulfaisodimidine • Sulfamethizole • Sulfadimidine • Sulfapyridine • Sulfafurazole • Sulfanilamide • Sulfathiazole • Sulfathiourea
Intermediate-acting sulfonamides	Sulfamethoxazole • Sulfadiazine • Sulfamoxole
Long-acting sulfonamides	Sulfadimethoxine • Sulfalene • Sulfametomidine • Sulfametoxydiazine • Sulfamethoxypyridazine • Sulfaperin • Sulfamerazine • Sulfaphenazole • Sulfamazon
Combinations	Sulfamethoxazole and trimethoprim
Other	Mafenide • Prontosil • Sulfacetamide • Sulfasalazine • Sulfisoxazole