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Strabismus (protein)
Strabismus was originally identified as a Drosophila protein involved in planar cell polarity [1]. Flies with mutated stranismus genes have altered development of omatidia in their eyes. Vertebrates have two Strabismus-related proteins, VANGL1 and VANGL2 (an alternate name for the Drosophila "Strabismus" protein is "Van Gogh"). Additional recommended knowledgeThe amino acid sequence and localization studies for Strabismus indicate that it is a membran protein. Prickle is another protein in the planar cell polarity signaling pathway. Prickle is recruited to the cell surface membrane by strabismus[2]. In cells of the developing Drosophila wing, Prickle and Strabismus are concentrated at the cell surface membrane on the most proximal side of cells[3]. Vertebrate cell movement
VANGL2 is involved in the migration of groups of cells during vertebrate embryogenesis[4]. References
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Strabismus_(protein)". A list of authors is available in Wikipedia. |