Strabismus (protein)

Strabismus was originally identified as a Drosophila protein involved in planar cell polarity ^[1]. Flies with mutated stranismus genes have altered development of omatidia in their eyes. Vertebrates have two Strabismus-related proteins, VANGL1 and VANGL2 (an alternate name for the Drosophila "Strabismus" protein is "Van Gogh").

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The amino acid sequence and localization studies for Strabismus indicate that it is a membran protein. Prickle is another protein in the planar cell polarity signaling pathway. Prickle is recruited to the cell surface membrane by strabismus^[2]. In cells of the developing Drosophila wing, Prickle and Strabismus are concentrated at the cell surface membrane on the most proximal side of cells^[3].

Vertebrate cell movement

VANGL2 is involved in the migration of groups of cells during vertebrate embryogenesis^[4].

References