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Spectinomycin


Spectinomycin
Systematic (IUPAC) name
(2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)- 4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino) decahydro-4H-pyrano[2,3-b][1,4]benzodioxin-4-one
Identifiers
CAS number	1695-77-8
ATC code	J01XX04
PubChem	15541
DrugBank	APRD01232
Chemical data
Formula	C₁₄H₂₄N₂O₇
Mol. mass	332.35 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	B(US)
Legal status
Routes	?

Spectinomycin (marketed as the hydrochloride salt spectinomycin hydrochloride under the trade name Trobicin) is an aminocyclitol antibiotic produced by the bacterium Streptomyces spectabilis.

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Mechanism

It binds to the 30S ribosomal subunit in invading bacteria and interrupts protein synthesis.

Uses

It is given by injection to treat gonorrhea, especially in patients who are allergic to penicillins.

Side effects

Side effects include itching, chills, stomach-ash, and red rash.

v • d • e Antibacterials for systemic use: aminoglycosides (J01G)
-mycin (Streptomyces)	Kanamycin • Neomycin • Streptomycin • Tobramycin • Paromomycin • Hygromycin B • Spectinomycin
-micin (Micromonospora)	Gentamicin • Netilmicin • Sisomicin
Other	Amikacin

v • d • e Antibacterials for systemic use: others (J01X)
Glycopeptide	Vancomycin - Teicoplanin
Polymyxins	Colistin - Polymyxin B
Steroid antibacterials	Fusidic acid
Imidazole derivatives	Metronidazole - Tinidazole - Ornidazole
Nitrofuran derivatives	Nitrofurantoin - Nifurtoinol
Other	Fosfomycin - Xibornol - Clofoctol - Spectinomycin - Methenamine - Mandelic acid - Nitroxoline - Linezolid - Daptomycin - Hitachimycin - Dalbavancin - Telavancin