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Sodium phenylbutyrate
Sodium phenylbutyrate is an orphan drug, marketed by Ucyclyd Pharma (Hunt Valley, USA) under the trade name Buphenyl® and by Orphan Europe (France) as Ammonaps®. Additional recommended knowledgeIt has been used to treat urea cycle disorders.[1] Scanadinavian Formulas, Inc. Sellersville, PA supplies Sodium Phenylbutyrate worldwide for clinical trials. MetabolismPhenylbutyrate is a prodrug. In the human body it is metabolized by beta-oxidation to phenylacetate. Phenylacetate conjugate with glutamine to phenylacetylglutamine, that is eliminated with the urine.
ResearchSodium phenylbutyrate is also under investigation for the treatment of some sickle-cell disorders (Blood Products Plasma Expanders and Haemostatics) and for use as a potential differentiation-inducing agent in malignant glioma and acute myeloid leukaemia. PBA has been associated with longer lifespans in Drosophila.[2] References
Categories: Orphan drugs | Prodrugs |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Sodium_phenylbutyrate". A list of authors is available in Wikipedia. |