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Signal peptide peptidaseThe Signal Peptide Peptidase (SPP) and its homologs (SPPL2a/b/c, SPPL3) are a class of transmembrane aspartyl proteases with the conserved motives YD ... GxGD ...PALL. Their sequences are highly conserved in different vertebrate species. Their substrates are Type II transmembrane proteins.[1] Additional recommended knowledgePhysiologically SPP processes signal peptides of HLA preproteins. A 9 AS cleavage fragment is then presented on HLA-E receptors and modulates the activity of natural killer cells.[2] SPP also plays a pathophysiolocigal role; it cleaves the core protein of Hepatitis C virus and thus influences the reproduction rate of HCV.[3] SPPL2a/b promotes the intramembrane cleavage of TNFα in activated dendritic cells and might play an immunomodulatory role.[4][5] References
Further reading
Categories: Integral membrane proteins | Protein targeting | Hydrolases |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Signal_peptide_peptidase". A list of authors is available in Wikipedia. |