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Sigma-2 receptor

The sigma-2 receptor is a sigma receptor which preferentially binds to siramesine^[1] and PB28.^[2]

Unlike sigma-1 receptor, it has not yet been cloned.

Activation of the receptor can cause apoptosis.^[3]

References

^ Skuza G, Rogóz Z (2006). "The synergistic effect of selective sigma receptor agonists and uncompetitive NMDA receptor antagonists in the forced swim test in rats". J. Physiol. Pharmacol. 57 (2): 217-29. PMID 16845227.
^ Cassano G, Gasparre G, Contino M, et al (2006). "The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells". Cell Calcium 40 (1): 23-8. doi:10.1016/j.ceca.2006.03.004. PMID 16687172.
^ Wayne D. Bowen - MPPB Faculty :: Brown University. Retrieved on 2007-06-16.

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