Serotonin uptake inhibitor

A serotonin uptake inhibitor is a drug which acts as a neurotransmitter uptake inhibitor on serotonin receptors.

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The most well known members of this class are the selective serotonin reuptake inhibitors (SSRI)s. However, there also exist non-selective inhibitors. In some cases, such as the older antidepressants clomipramine and trazodone, this lack of selectivity is seen as a disadvantage, and is one of the reasons those drugs are currently prescribed less frequently. In other cases, such as duloxetine and milnacipran, the lack of selectivity is considered part of the normal profile of the medication, and it is classified accordingly.

Examples of serotonin uptake inhibitors include:^[1]

References

^ MeSH list of agents 82017367

v • d • e Receptor agonists and antagonists (and reuptake inhibitors)
Dopamine receptor	Dopamine agonist - Dopamine antagonist - Dopamine reuptake inhibitor
5-HT (serotonin) receptor	Serotonin receptor agonist - Serotonin antagonist (5-HT₃ antagonist) - Serotonin uptake inhibitor (SSRI)
Adrenergic receptor	adrenergic agonist (Adrenergic alpha-agonist, Beta2-adrenergic receptor agonist) - adrenergic antagonist (Alpha blocker, Beta blocker) - Adrenergic uptake inhibitor
Acetylcholine receptor	cholinergic (Muscarinic agonist, Nicotinic agonist) - anticholinergic (Muscarinic antagonist, Nicotinic antagonist) - Acetylcholinesterase inhibitor
Histamine receptor	Histamine agonist - Histamine antagonist (H₁, H₂)
GABA receptor	GABA agonist - GABA antagonist
NMDA receptor	NMDA antagonist

v • d • e

Psychoanaleptics: antidepressants (N06A)

MAOIs

Iproclozide • Iproniazid • Isocarboxazid • Nialamide • Pargyline • Phenelzine • Rasagiline • Selegiline • Toloxatone • Tranylcypromine
RIMAs: Brofaromine • Beta-carbolines (Harmaline) • Moclobemide

RIs

S RI	SS RI (Alaproclate, Citalopram, Dapoxetine, Escitalopram, Etoperidone, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Zimelidine) • TCAs/Tetras (Clomipramine, Nefazodone, Trazodone)
N RI / A RI	Atomoxetine • Maprotiline • Reboxetine • Viloxazine • TCAs/Tetras (Amitriptyline, Amoxapine, Butriptyline, Desipramine/Lofepramine, Dibenzepin, Dothiepin, Doxepin, Imipramine, Iprindole, Melitracen, Nortriptyline, Opipramol, Protriptyline, Trimipramine, Maprotiline)
D RI	Vanoxerine • Phenmetrazine • TCAs (Amineptine)
SN RI	Bicifadine • Desvenlafaxine • Duloxetine • Milnacipran • Nefazodone • Venlafaxine
ND RI	Bupropion
SND RI	Brasofensine • Tesofensine • Nomifensine