Serine hydrolase

The serine hydrolase superfamily is one of the largest known enzyme families comprising approximately 1% of the genes in the human genome. This family includes:

• serine proteases like trypsin
• lipases like pancreatic lipase, hormone sensitive lipase, and triacylglycerol lipase
• esterases
• acetylcholinesterase
• thioesterases
• certain phospholipases like phospholipase A2
• some amidases like fatty acid amide hydrolase

Additional recommended knowledge

What is the Correct Way to Check Repeatability in Balances?

Daily Sensitivity Test

Essential Laboratory Skills Guide

all of these enzymes share a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine) although variations on this mechanism exist.

See also

• Enzyme
• List of enzymes
• Ester
• Amide
• Thioester
• Activity based proteomics